Chronic Pancreatitis Flashcards
1
Q
what is it
A
long term fibrosis and calcification with irreversible structure changes to pancreas
2
Q
what is pathology
A
replacement of pancreas by chronic inflammation, fibrosis and scar tissue
destruction of exocrine acini and endocrine islets
3
Q
what does this lead to
A
endocrine insufficiency and exocrine insufficiency
4
Q
what are causes
A
alcohol abuse but can be hereditary
5
Q
what is hereditary chronic pancreatitis associated with
A
CF
alpha-1-antitrypsin deficiency
hyperparathyroidism
6
Q
what are symptoms
A
chronic abdominal pain
steatorrhoea
7
Q
how to diagnose
A
amylase may be normal
CT may show calcification, dilated duct
8
Q
how is it treated
A
stop alcohol consumption opioids, NSAIDs for pain address diabetes (endocrine) enzyme supplements eg CREON (exocrine) surgery if intolerable (join duodenum/jejunum to pancreas so pancreatic juice can drain)
