7.1. Metabolic Bone Disease - Bone Physiology and Rickets Flashcards Preview

3rd Year - MSK Diseases > 7.1. Metabolic Bone Disease - Bone Physiology and Rickets > Flashcards

Flashcards in 7.1. Metabolic Bone Disease - Bone Physiology and Rickets Deck (10):
1

What causes the Bone Resorption, in the Bone Re-modelling Cycle?

Osteoclasts

2

What forms Osteoclasts?

1. Myeloid Progenitor Cells
2. Pre-Osteoclast
3. Osteoclast

3

What causes the Bone Formation, in the Bone Re-modelling Cycle?

Osteoblasts

4

What forms Osteoblasts?

1. Mesenchymal Progenerator Cells
2. Pre-Osteoblast
3. Osteoblast

5

What causes in increase in Osteoblast action?

1. Vitamin D
2. Glucocorticoids
3. TNF-Alpha
4. IL-1, IL-11
5. PTH, PTHrP
6. PGE2

6

What organs can cause Vitamin D related disorders?

1. Skin
2. Liver
3. Kidney

7

What does Vitamin D influence the regulation of?

Vitamin D stimulates Absorption of Calcium and Phosphate from the gut

8

What happens to the Calcium and Phosphate in the Blood?

It is available for Bone Mineralisation

9

What does severe nutritional Vitamin D or Calcium deficiency cause?

Insufficient Mineralisation and thus:
1. a) Rickets in a growing child
1. b) Osteomalacia in the adult
2. Muscle Function Impairment

10

What are the symptoms of Rickets, in a growing Child?

1. Stunted Growth with an odd curve in the Spine
2. Large Forehead
3. Odd-shaped ribs + Wide Abdomen
4. Wide Joints at the Elbow, Wrist and Ankle
5. Odd Shaped Legs
6. Wide Bones

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