8.2. Mulit-System Autoimmune Disease - Systemic Vasculitis Diseases Flashcards Preview

3rd Year - MSK Diseases > 8.2. Mulit-System Autoimmune Disease - Systemic Vasculitis Diseases > Flashcards

Flashcards in 8.2. Mulit-System Autoimmune Disease - Systemic Vasculitis Diseases Deck (18):
1

What are the 3 types of Blood Vessels, affected by Systemic Vasculitis Diseases?

1. Large Vessel Vasculitis
2. Medium Vessel Vasculitis
3. Small Vessel Vasculitis

2

What is the common Large Vessel Vascuilitis Condition?

Giant Cell Arteritis

3

What are the common Medium Vessel Vascuilitis Conditions?

1, Polyarteritis Nodosa
2. Kawasaki Disease

4

What are the common Small Vessel Vascuilitis Conditions?

These are known as ANCA-Associated Vasculitis and include:
1. Granulomatosis Polyangiitis (Wegner's Granulomatosis)
2. Microscopic Polyangiitis
3. Eosinophilic Granulomatosis Polyangiitis

5

What is Giant Cell Arteritis?

Inflammation of the Arterial Wall with Fragmentation and Disruption of the Internal Elastic Lamina

6

What is the Diagnostic Criteria for Giant Cell Arteritis?

3 of the following:
1. Age at onset ? 50 years
2. New Headache
3. Temporal Artery Tenderness / Reduced Pulsation
4. ESR > 50
5. Abnormal Temporal Biopsy

7

What are the 3 ANCA-associated Vasculitis Conditions?

1. Wegner's Granulomatosis - Granulomatosis with Polyangiitis
2. Microscopic Polyangiitis
3. Eosinophilic Granulomatosis with Polyangiitis

8

What is the pathophysiology of Wegner's Granulomatosis (Granulomatosis with Polyangiitis)?

Necrotising Granulomatous Inflammation (involving the Respiratory Tract)

9

What size vessels does Wegner's Granulomatosis (Granulomatosis with Polyangiitis) affect?

Small - Medium Vessels

10

What is commonly associated with Wegner's Granulomatosis (Granulomatosis with Polyangiitis)?

Necrotising Glomerulonephritis

11

What is the pathology of Microscopic Polyangiitis?

1. Necrotising Vasculitis (with few/no immune deposits)
2. Necrotising Arteritis

12

What size Vessels does Microscopic Polyangiitis commonly affect?

Small - Medium
Note - Mainly small

13

What is commonly associated with Microscopic Polyangiitis?

1. Necrotising Glomerulonephritis
2. Pulmonary Capillaritis

14

Is Granulomatous Inflammation present in Microscopic Polyangiitis?

No - Few / No immune deposits

15

What is the pathophysiology of Eosinophilic Granulomatosis with Polyangiitis?

Eosinophil Rich and Necrotising Granulomatous Inflammation (involving the Respiratory Tract)

16

What size Vessels does the Necrotising Vasculitis, associated with Eosinophilic Granulomatosis with Polyangiitis, affect?

Small - Medium Vessels

17

What is commonly associated with Eosinophilic Granulomatosis with Polyangiitis?

1. Asthma
2. Eosinophilia

18

What is the relationship between ANCA and Glomerulonephritis?

ANCA is more frequent when Glomerulonephritis is present

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