HUMAN GUT FINAL DECK

Question 1

Lederberg, 2001?

Answer 1

Human gut microbiome =, genomes, indigenous microbiota, gut

Question 2

Zhu, 2010?

Answer 2

Via, human microbiome project, 1000 bacterial species, firmicutes, bacteriodites, shared core

Low resolution surveys to NGS sequencing + advanced bioinformatics

Question 3

Hay, 1992?

Answer 3

IBD + Chrons = $1.8-$2.6 billion

Question 4

Wolf, 1994?

Answer 4

Obesity, association, $68.8 billion

Question 5

Morgan, 2012?

Answer 5

Chrons, GI tract, immune disorder

Genome studies, found churns, affects loci, innate + adaptive response, affected commensal bacteria

Facaelibacterium reduced, metabolize, polysaccharides, N-acetyl glucosamine, anti-inflammatory

Question 6

Borody, 2012?

Answer 6

Paratuberculosis = chrons

Reversal achieved, anti paratuberculosis, proves involvement + potential

Question 7

Khan, 2016?

Answer 7

Obesity, dietary, lifestyle, host genetics, doesn’t explain worldwide, excess energy in obese, therapeutic manipulation, energy storage

If escape gut digestion, colon digestion, microbiota, produce short chain fatty acids, correlate fat accumulation

SCFA fecal, obesity associated

Question 8

Zhang, 2015?

Answer 8

Metaformin, berberine, diabetes treatment, modulate, microbiota, rats, SCFA bacteria increase, disagree