ANTI VIRUELNCE FINAL DECK

Question 1

Johnson, 1991?

Answer 1

Virulence factors = ,Properties, products, structures, overcome, host defences, colonise or invade

Question 2

Lenski, 1998?

Answer 2

Economic cost of antibiotics

Question 3

Miller, 2001?

Answer 3

Quorum sensing, control, gene expression, fluctuations, cell population density, cause disease

Question 4

Rasko, 2010?

Answer 4

Regulated, AHL’s, gene expression, virulence factors, biofilm formation

Interferring agents, agonis, inhibitors, AHL’s, Enzymes or antibodies

Prevent signal, prevent disease

Question 5

Dong, 2005?

Answer 5

Quorum quenching, AHL degradtion enzymes, from bacteria, disable AHL

Question 6

Lin, 2003?

Answer 6

Ralstonia SP, bacterium, gene cloned, for AHL deactivation, effective, in Escherichia Coli

Question 7

Simoes, 2010?

Answer 7

Biofilms, extracellular, matrix, community, free swimming to surface attached, resistant phenotype, difficult to eradicate, foodbourne pathogen

Transport, planktonic cells, liquid to surface, adsorption of cells at surface, cell-cell signalling molecules produced, transport within biofilm

Substrate metabolism, cell growth, replication, EPS production

Question 8

Lee, 2014?

Answer 8

Staphylococcus aureus, human pathogen, a toxin, haemolytic
Biofilm, aids virulence
Cis nerolidol, oil, plants, flowers, inhibited formation, then, haemolytic activity, then a-toxin gene hla
Hence anti virulent