Bone Healing and Fracture Nonunion

Question 1

Akagi, VCOT, 2013:
Autogenous cancellous bone and FGF-2 combined with frozen allografts in femoral nonunions

Callus formation?

Answer 1

Akagi, VCOT, 2013:

Callus formation was not remarkable

Question 2

Minier, VCOT, 2014:

Bone regeneration in rhBMP-2 constructs vs cancellous bone autograft constructs?

Answer 2

Minier, VCOT, 2014:

Bone regeneration appeared to develop earlier in the rhBMP-2 constructs than the cancellous bone autograft constructs but similar results were obtained at 20 weeks post-op

Question 3

Might, VCOT, 2016:

Hydrogels appeared to prevent bone growth and even caused bone lysis - true or false?

Answer 3

Might, VCOT, 2016:

True

Question 4

Massie, VCOT, 2017:
Nonunions treated with fixation, compression resistant matrix and rhBMP-2

1. Minor complication rate?
2. Major complication rate?
3. Functional outcomes?
4. There was a delay in healing in what types of fractures?
5. What was most apparent at 3-5 days post-op?

Answer 4

Massie, VCOT, 2017:

1. 73% minor complication rate
2. 18% major complication rate
3. 82% returned to full function, 18% had acceptable function
4. Delay in healing in humeral condylar fractures compared to diaphyseal fractures
5. Significant inflammation and swelling were most apparent at 3-5 days post-op

Question 5

Field and Ruthenbeck, VCOT, 2018:

1. Pattern of optical density measures during fracture healing?
2. Correlation between optical density measures and the qualitative measure of bridging callus and the radiographic union score for tibial fractures (RUST)?

Answer 5

Field and Ruthenbeck, VCOT, 2018:

1. Optical density measures decreased through 4 weeks post-op (resorptive phase) and then gradually and consistently increased at 8-16 weeks post-op
2. Optical density measures showed strong correlation with measures of bridging callus and RUST