EXAM #2 AEs Flashcards

1
Q

AE of Loops? Which is worse?

A

Ototoxicity

- Worse with Ethacrynic Acid

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2
Q

AE of Loops AND Thiazides?

A

Hypokalemic alkalosis

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3
Q

AE of Thiazides (2)? Exception?

A
  • Hyperglycemia

- Increase lipids (except Indapamide)

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4
Q

AE of ACE-I (2)?

A
  • Dry cough

- Angioedema

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5
Q

AE of Digoxin (2)?

A
  • FIRST: GI

- Cardiac (bigeminy, VFib)

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6
Q

What group of medications decrease glucose tolerance?

A

Diuretics

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7
Q

AE of Clonidine AND Methyldopa (2)?

A
  • Sedation

- Xerostomia

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8
Q

AE of Methyldopa?

A

Hemolytic anemia (+Coombs)

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9
Q

AE of Prazosin?

A
  • First dose phenomenon
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10
Q

AE of Labetolol?

A

Hepatotoxicity

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11
Q

AE of Hydralazine?

A

HIP (slow acetylators)

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12
Q

AE of Sodium nitroprusside? In what population especially?

A

CYANIDE

- Especially if kidney disease

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13
Q

AE of Nifedipine (2)?

A

Worst for reflex tachycardia

- Gingival hyperplasia

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14
Q

AE of Verapamil (2)?

A
  • Constipation

- Cardiac depression

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15
Q

AE of Nitrates? What if chronic use?

A
  • Throbbing HA

Chronic: Monday disease

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16
Q

AE of Sildenafil (2)?

A
  • Drug interactions

- Visual impairment (blue light)

17
Q

AE of Statins (3)?

A
  • Increase LFTs (liver issues)
  • Increase CK (skeletal issues)
  • Drug interactions (CYP3A4)
18
Q

AE of Niacin?

A

Flushing

19
Q

AE of Fibrates?

A

GALLSTONES

20
Q

AE of ALL Arrhythmics?

A

Arrhythmias

21
Q

What type of Arrhythmics cause Torsade de Pointe? Which two drugs cause it?

A

If APD increased = QT prolongation

  • Quinidine
  • Sotalol
22
Q

What drug does NOT cause Torsade de Pointe?

A

Amiodarone

23
Q

AE of Procainamide?

A

HIP (slow acetylators)

24
Q

AE of Lidocaine (2)?

A
  • Convulsions

- Least negative inotropic

25
Q

AE of Amiodarone (3)?

A
  • Pulmonary fibrosis
  • Deposit in tissues/cornea
  • Thyroid dysfunction (iodide)
26
Q

AE of Heparin?

A

HIT

27
Q

AE of Dabigatran (Pradaxa)?

A

Sudden withdrawal

28
Q

AE of Warfarin (2)?

A
  • Drug interactions

- Quickly reduce Protein C = can cause clotting

29
Q

AE of Clopidogrel (2)?

A
  • Drug interactions

- Sudden withdrawal