Thyroid (Exam #3)

Question 1

Is hypothyroidism associated with high I- or low I-?

Answer 1

LOW I-

Question 2

Is hyperthyroidism associated with high I- or low I-?

Answer 2

HIGH I-

Question 3

Sxs of weight gain, cold sensitivity, fatigue are indicative of what?

Answer 3

Hypothyroidism

- Myxedema coma if severe

Question 4

The function of what enzyme MUST be good in order to administer Levothyroxine (Synthroid)?

Answer 4

Peripheral deiodinases

- Converts T4 to T3

Question 5

Which Hypothyroid medication is used as initial therapy? Which is used as maintenance? Why is this?

Answer 5

Liothyronine sodium = T3 = initial
- Faster steady state so acts fast

Levothyroxine (Synthroid) = T4 = maintenance
- Takes 5 weeks to reach study state so takes time to work

Question 6

Of the three Hypothyroid medications, which involves T4? T3? T4 AND T3?

Answer 6

• Levothyroxine (Synthroid) = T4
• Liothyronine sodium = T3
• Desiccated Thyroid = T4 AND T3

Question 7

Sxs of tachycardia, heat sensitivity, tremor, insomnia, diarrhea, fatigue are indicative of what?

Answer 7

Hyperthyroidism

Question 8

Four treatment options for Hyperthyroidism?

Answer 8

• BB for sxs relief
• Thioamides or Iodide (reduce T4, T3)
• 131I
• Surgery

Question 9

Which Hyperthyroid medication is used short-term? Which is used as maintenance? Why is this?

Answer 9

• Iodide = short-term

- Thioamides = maintenance (gradual effects)

Question 10

Use of Iodide (2)?

Answer 10

• 7-10 before surgery (SHORT TERM ONLY)

- Radioacative emergency

Question 11

For what two reasons would PTU be used over Methimazole?

Answer 11

• Pregnancy

- Allergy to Methimazole

Question 12

Two uses of Radioactive Iodine (131I)?

Answer 12

• Diagnostic = small amounts

- Destroy thyroid gland = large amounts