Osteoporosis (Exam #3) Flashcards
1
Q
What four medications inhibit osteoclasts?
A
- Estrogen
- Calcitonin
- Bisphosphonates
- Denosumab
2
Q
What two medications activate osteoblasts?
A
- PTH
- Vitamin D
3
Q
What two effects do ALL osteoporosis drug have?
A
- Increase bone density
- Decrease osteoporotic fractures
4
Q
What are the only two anabolic drugs used to treat osteoporosis? How do these differ?
A
- Teriparatide = INTERMITTENT administration
- Abaloparatide
5
Q
What is rhPTH used to treat?
A
Hypothyroidism
6
Q
What is rhPTH used to treat?
A
Hypothyroidism
7
Q
What are the four Bisphosphonates (think name hint), and what are their admin routes?
A
“-dronate”
- Alendronate = oral
- Risedronate = oral
- Ibandronate = oral AND IV
- Zoledronic Acid = IV
8
Q
Important PK of Alendronate, Risedronate, Ibandronate, Zoledronic Acid? How does this change administration (2)?
A
Poor oral absorption
- Take on empty stomach
- Take with 1/2 glass of water ONLY
