Syphilis Flashcards

1
Q

syphilis bacteria type

A

Treponema pallidum –> spirochete (spiral-shaped) bacteria

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2
Q

how is Treponema pallidum bacteria spread

A
  • through shedding lesions containing microbial particles during sexual contact
  • placental transmission from infected mother to baby
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3
Q

systemic cmplx

A

blindness, paralysis, heart disease & death

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4
Q

why do systemic cmplx occur

A

d/t bacteria entering circulatory & lymphatic systems

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5
Q

1st stage

A
  • painless, non-bleeding, oval-shaped ulcer/chancre at contact sites
  • regional lymphadenopathy
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6
Q

1st stage ulcer healing duration

A

heals in ~3-12 wks

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7
Q

quick healing in 1st makes pt speculate what

A

thinking they’re cured although they’re still infected (lesion is just not present)

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8
Q

regional lymphadenopathy

A

Bacteria in lymphatic system causing infection & resulting inflm of lymph nodes (swollen lymph nodes)

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9
Q

2nd stage duration

A

up to 6 months

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10
Q

when does 2nd stage begin

A

6-8 wks post-infection

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11
Q

2nd stage characteristics

A
  • maculopapular (spotty, pimple-like) rash on palms of hands & soles of feet
  • patches on mucous membranes
  • flat papules
  • generalized lymphadenopathy
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12
Q

symptoms of 2nd stage

A

fever, malaise

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13
Q

2nd stage latent period

A

can last up to 50 yrs (pt asympt while advancing subclinically)

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14
Q

when does 3rd stage occur

A

~1-35 yrs after 1st infection (if untreated)

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15
Q

3rd stage characteristics

A

irreversible damage to bones, joints, CVS, and NS

bacteria can still be eradicated

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16
Q

Tx

A

long-acting Abx (ex. Penicillin)

17
Q

why is a long-acting Abx used for treatment

A

Spirochetes have a long generation time of ~30 hours

the time it takes for their colony to double in size, versus for example, E. Coli’s generation time of 20 minutes