A. VI

Question 1

Hypersensitivity reaction=

Answer 1

Pathological immune response to otherwise harmless Ag

Question 2

Type I HSN

Answer 2

IgE mediated, mast cell activation

Question 3

Type I HSN stages

Answer 3

Immediate (Mast cell release histamine and tryptase)

Late (Chemokine attract inflammatory cells)

Question 4

Type I HSN examples

Answer 4

Anaphylaxis

Allergic asthma

Question 5

Type II HSN

Answer 5

Ab mediated. Binds cell surface Ag and attracts NK

B for II

Question 6

Type II HSN examples

Answer 6

Autoimmune hemolytic anemia
Transfusion reaction
Rheumatic fever
MG
Graves disease

Question 7

Type III HSN

Answer 7

Immune Complex Ag-Ab complex activate complement which attracts neut -> release lysosomal enymes

C for III

Question 8

Type III HSN examples

Answer 8

SLE
Polyarthritis nodosa
PSGN

Question 9

Type IV HSN (two mechanism)

Answer 9

Delayed, cell mediated

1. CD8+ T cell kill target cell
2. CD4+ T cell recognizes Ag and release cytokines

Question 10

HSN I-III are all _____ mediated

Answer 10

Ab

Question 11

Type IV HSN examples

Answer 11

Contact dermatitis
PPD skin test
Graft vs host disease

Question 12

Autoimmune disorders are characterized by

Answer 12

Immune-mediated damage of tissue

Question 13

Autoimmune disorders involves loss of

Answer 13

Self-tolerance

Question 14

Autoimmune disorders are more common in

Answer 14

Women of childbearing age

Question 15

Etiology of Autoimmune disorders

Answer 15

Likely an inviormental trigger in genetically susceptible individuals

Question 16

What happens in SLE?

Answer 16

Ab against the host damage multiple tissue

Question 17

HSN II=

Answer 17

Cytotoxic

Question 18

HSN III=

Answer 18

Ag-Ab complex

Question 19

SLE includes what type of HSN reaction?

Answer 19

II+III

Question 20

SLE clinical features

Answer 20

Fever
Weight loss
Butterfly rash
Arthritis
Pleuritis
Pericarditis
Cns psychosis
Renal damage
Endocarditis
Myocarditis
Anemia
Trhombocytopenia
Leukemia

Question 21

Most common renal damage in SLE?

Answer 21

Diffused proliferative glomerulonephritis

Question 22

What type of endocarditis is common in SLE?

Answer 22

Libman Sacks Endocarditis

LSE on SLE

Question 23

Libman sacks endocarditis characterized by

Answer 23

small, sterile deposits on both sides of the mitral valve

Question 24

Libman sacks endocarditis affects which valve?

Answer 24

Mitral

Question 25

SLE symptoms by mnemonic

Answer 25

RASH OR PAIN ``` Rash Arthritis Serositis Hematologic disorders Oral ulcers Renal disease Photosensitivity Antinuclear Ab Immunologic disorders Neurologic disorders ```

Question 26

Which syndrome is associated with 30% SLE cases?

Answer 26

Antiphospholipid Ab syndrome

Question 27

Antiphospholipid Ab syndrome results in

Answer 27

Arterial and venous thrombosis

Question 28

Sjorgen syndrome=

Answer 28

Autoimmune destruction of lacrimal and salivary glands (exocrine glands)

Question 29

Sjorgen syndrome is a type __ HSN

Answer 29

IV

Question 30

Sjorgen syndrome is _______ mediated damage with ________

Answer 30

Lymphocyte mediated damage with fibrosis

Question 31

Sjorgen syndrome classically presents with

Answer 31

``` Dry eyes (no tears) Dry mouth (no saliva) Recurrent dental carries ```

Question 32

Dry mouth is also called

Answer 32

Xerostomia

Question 33

Sjorgen syndrome often associated with what other syndrome?

Answer 33

Rheumatoid arthritis

Question 34

Sjorgen syndrome posses an increase risk for

Answer 34

B cell lymphoma in the parotid gland | MALT lymphoma

Question 35

Sjorgen syndrome characterized by the presence of which Ab?

Answer 35

Anti Nuclear Ab | Antiribonucleoprotein Ab

Question 36

Antiribonucleoprotein Ab present in Sjorgen syndrome

Answer 36

SS-A (Anti-Ro) | SS-B (Anti-La)

Question 37

Scleroderma=

Answer 37

Autoimmune tissue damage with activation of fibroblasts and deposition of collagen (Fibrosis) Systemic sclerosis!!

Question 38

Scleroderma is devided into 2

Answer 38

Diffused | Localized

Question 39

Diffused Scleroderma=

Answer 39

Skin and early visceral involvment

Question 40

Which organ is usually affected by Diffused Scleroderma

Answer 40

Esophagus

Question 41

Diffused Scleroderma is characterized by which Ab

Answer 41

Anti Nuclear Ab | Anti-DNA (Scl-70)

Question 42

Localized Scleroderma=

Answer 42

Local skin and late visceral involvment

Question 43

Localized Scleroderma is associated with what mnemonic syndrome

Answer 43

CREST ``` Calcinosis cutis Raynaud phenomenon Esophagus dysmotility Sclerodactyly Telangietasia ```

Question 44

Rheumatoid arthritis=

Answer 44

Chronic, systemic autoimmune disease

Question 45

Rheumatoid arthritis is associated with what genetics?

Answer 45

HLA-DR4

Question 46

Hallmark of Rheumatoid arthritis

Answer 46

Synovitis

Question 47

Synovitis leads to

Answer 47

Pannus= inflamed granulation tissue

Question 48

Rheumatoid arthritis leads to destruction of

Answer 48

Cartilage

Question 49

Rheumatoid arthritis leads to destruction of Cartilage and

Answer 49

ankylosis= fusion of joints

Question 50

Clinical features of Rheumatoid arthritis

Answer 50

``` Arthritis with morning stiffness that improves with activity Fever Vasculitis Baker cyst Pleural effusion ```

Question 51

Which fingers joints are involved in Rheumatoid arthritis?

Answer 51

PIP

Question 52

Laboratory findings in Rheumatoid arthritis

Answer 52

IgM Ab against Fc region of IgG (Rheumatoid factor)

Question 53

What is Rheumatoid factor

Answer 53

Antibody against the Fc portion of IgG