Act 7

Question 1

a disperse system in which internal phase is
dispersed uniformly as dinely divided insoluble
particles throughout the external phase.

Answer 1

Suspension

Question 2

Suspension is a a disperse system in which ___________ is
dispersed uniformly as dinely divided insoluble
particles throughout the ________

Answer 2

internal phase; external phase.

Question 3

consist of insoluble solid particles
having the range of 0.5 to 5 microns
which is maintained uniformly
throughout the suspending vehicle.

Answer 3

Internal Phase

Question 4

generally aqueous and in some
instances it may be an organic liquid or
oily liquid for non-oral use

Answer 4

External Phase

Question 5

Suspensions Based on General Classes

Answer 5

○ Oral suspension
○ Externally Applied suspension
○ Parenteral Suspension

Question 6

Suspensions Based on Proportion of Solid Particles

Answer 6

○ Diluted suspension
○ Concentrated suspension

Question 7

Suspensions Based on Electro Kinetic Nature of Solid
Particles

Answer 7

○ Flocculated suspension
○ Deflocculated suspension

Question 8

Suspensions Based on Size of Solid Particles

Answer 8

○ Colloidal suspension
○ Coarse suspension

Question 9

REASONS FOR THE FORMULATION OF A SUSPENSION

Answer 9

● Sustaining effect
● Stability
● Taste
● basic solubility

Question 10

COMPONENTS OF A SUSPENSION

Answer 10

API
Wetting agents
Flocculating agents
Viscosity Agents
Buffer
Preservative, colorant, flavorant
Water, glycerin, sorbitol

Question 11

The API in Suspensions is (soluble/insoluble) in vehicle

Answer 11

insoluble

Question 12

Also known as surfactants

Answer 12

Wetting agents

Question 13

added to disperse solid particles in
the external phase

Answer 13

Wetting agents

Question 14

Sodium lauryl sulfate, benzalkonium
chloride

Answer 14

Wetting agents

Question 15

Agents which are capable of preventing the
caking of suspended particles

Answer 15

Flocculating agents

Question 16

calcium chloride, aluminum chloride

Answer 16

Flocculating agents

Question 17

Also known as suspending agents or
thickeners

Answer 17

Viscosity agents

Question 18

Added to increase viscosity of the
suspension

Answer 18

Viscosity agents

Question 19

methylcellulose, bentonite, tragacanth

Answer 19

Viscosity agents

Question 20

Added to stabilize the suspension in the
desired pH range

Answer 20

Buffer

Question 21

Aluminum Magnesium Hydroxide Suspension is an

Answer 21

ANTACID.

Question 22

Antacids are substances which reduce the gastric
acidity resulting in an (decrease/increase) in the pH of
the stomach and in the duodenum.

Answer 22

increase

Question 23

also used to neutralize excess gastric
hydrochloric acid associated with gastritis
and peptic ulcer.

Answer 23

Antacids

Question 24

Most antacids raise the gastric pH to ____.

Answer 24

4-5

Question 25

widely used for: ○Uncomfortable feeling from overeating ○ Heartburn ○ Dyspepsia (indigestion) ○ Duodenal ulcer ○ Other non-specific GI symptoms

Answer 25

Antacids

Question 26

Considered as an ideal antacid

Answer 26

ALUMINUM HYDROXIDE

Question 27

ALUMINUM HYDROXIDE is soluble in

Answer 27

acidic medium

Question 28

Color of Al(OH)3

Answer 28

White

Question 29

T/F: Al(OH)3 is a viscous suspension

Answer 29

T

Question 30

pH of Al(OH)3

Answer 30

pH 5.5 - 8.0

Question 31

Disadvantages of Al(OH)3

Answer 31

- may interfere with the 3 absorption of other drugs by binding with them - Can cause constipation due to the production of Aluminum Chloride

Question 32

White, fine odorless, amorphous powder

Answer 32

MAGNESIUM HYDROXIDE

Question 33

MAGNESIUM HYDROXIDE is Insoluble in water and alcohol but soluble in ________

Answer 33

dilute acids

Question 34

Laxatives in high doses

Answer 34

MAGNESIUM HYDROXIDE

Question 35

■ Fast onset of action ■ No systemic alkalosis ■ High Acid neutralizing capacity

Answer 35

MAGNESIUM HYDROXIDE

Question 36

■ Short duration of action ■ laxative/ diarrhea ■ Hypermagnesemia ■ Contraindicated to patients with kidney disease

Answer 36

MAGNESIUM HYDROXIDE

Question 37

wetting agent in prepping for Al(OH)3

Answer 37

Sorbitol Solution

Question 38

suspending agent in prepping for Al(OH)3

Answer 38

Carboxymethyl cellulose