Act 8

Question 1

A mixture of finely divided drugs and/or chemicals in
a dry form

Answer 1

POWDER

Question 2

2 forms of powders

Answer 2

○ Amorphous
○ Crystalline

Question 3

Powders according to size

Answer 3

V. coarse
Coarse
M. Coarse
Fine
V. Fine

Question 4

All particles pass through a
No. 8 sieve and not more
than 20% pass through a
No. 60 sieve

Answer 4

Very coarse

Question 5

All particles pass through a
No. 20 sieve and not more
than 40% pass through a
No. 60 sieve

Answer 5

Coarse

Question 6

All particles pass through a
No. 40 sieve and not more
than 40% pass through a
No. 80 sieve

Answer 6

Moderately coarse

Question 7

All particles pass through a
No. 60 sieve and not more
than 40% pass through a
No. 100 sieve

Answer 7

Fine

Question 8

All particles pass through a
No. 80 sieve. There is no
limit to greater fineness

Answer 8

Very fine

Question 9

Powders when to be used internally is administered through the

Answer 9

nose snuffs or Blown into a body cavity

Question 10

powders
applied as extreme finely
divided particles into a body
cavity such as, nose, ears,
throat, vagina with the help of a
device known as insufflators.

Answer 10

Insufflations

Question 11

Locally applied
non-toxic preparation and no systemic
effect. They are applied as lubricant,
protective, absorbent, antiseptic,
antipruritic, astringent, anti-perspirant

Answer 11

Dusting powders

Question 12

2 types of Dusting powders

Answer 12

Medical, Surgical

Question 13

Used to clean and
polish the teeth

Answer 13

Dentifrices

Question 14

Initially
dissolved in water to be used as
an antiseptic or cleansing agent
for a body cavity

Answer 14

Douche powder

Question 15

Douche powder and Dentifrices are powders used ____ (internally/externally)

Answer 15

externally

Question 16

Also known as undivided powders

Answer 16

Bulk powders

Question 17

Dusting powders, Effervescent,
Antacids, Laxatives, Dietary nutrient and
supplements,

Answer 17

Bulk powders

Question 18

simple mixture of the
prescribed medication without additional ingredients.
Dispensed usually involved bulk quantities

Answer 18

Oral undivided powders

Question 19

If intended for external dusting powders, Oral undivided powders can be placed in a

Answer 19

perforator or sifter

Question 20

If applied on skin, Oral undivided powders can be placed in a

Answer 20

aerosol container

Question 21

for easy removal
of a spoonful of powder, Oral undivided powders can be placed in a

Answer 21

a wide mouth glass

Question 22

Pockets, Mache, Capsules,

Answer 22

Divided powder

Question 23

contain one or more
active ingredient/s together with inner diluents
to produce a minimum quantity of 120 mg.

Answer 23

Divided powder

Question 24

T/F: Divided powder can be dispensed in a single-dose quantity,
usually folded in paper

Answer 24

T

Question 25

T/F: Divided powder can be dispensed in metal foil or small sealed or reusable plastic bag container

Answer 25

T

Question 26

REQUIREMENTS IN MANUFACTURING OF POWDER

Answer 26

HOMOGENEOUS BLENDING REDUCTION

Question 27

The purpose of this step is to increase the exposure of poorly soluble drug by increasing surface active area, thereby, improving dissolution rate

Answer 27

REDUCTION

Question 28

BLENDING TECHNIQUES

Answer 28

SPATULATION TRITURATION GEOMETRIC DILUTION SIFTING

Question 29

A method of blending a small amount of powder by movement of pharmaceutical spatula on a sheet of paper or ointment tile, in very little compression or compacting of the powder results from spatulation.

Answer 29

spatulation

Question 30

It is especially said for mixing solid substances that liquefy or form eutectic mixture.

Answer 30

spatulation

Question 31

- mixtures that melt at lower temperature than any other ingredients whether close and prolong contact with one another.

Answer 31

Eutectic mixture

Question 32

T/F Eutectic mixture is not suitable for large quantities of powder and not recommended for powders containing potent substances.

Answer 32

T

Question 33

Provides intimate building of powder using porcelain, wedgwood, glass mortar. Not recommended for eutectic mixtures

Answer 33

TRITURATION

Question 34

T/F In trituration, porcelain or ceramic mortar with erupt inner surface is prepared than a glass mortar with a smooth working surface

Answer 34

T

Question 35

T/F: A glass mortar is preferred for chemical substances that stains porcelain or ceramic surface as well as simple admixture of substance without a special need for comminution.

Answer 35

T

Question 36

Used for mixing potent substances with a large amount of diluent. Potent drug is placed on an approximately equal volume or amount of diluent in a mortar and mixed by trituration.

Answer 36

GEOMETRIC DILUTION

Question 37

Recommended on instances in which the potent and non-potent substances are of the same color or visible sign of thorough mixing is lacking.

Answer 37

GEOMETRIC DILUTION

Question 38

The simplest and most commonly used method of mixing powder or particle size determination.

Answer 38

SIFTING

Question 39

This involves tumbling a powder in a rotating chamber or mixing powder using a large enclosed container rotated by a motorized process.

Answer 39

TUMBLING

Question 40

Study of Particle Size. It is the science of small particles. It is important to study small particles since most drug dosage forms are solid.

Answer 40

Micromeretrics

Question 41

T/F: Solids are not static systems.

Answer 41

T

Question 42

The physical states of solids can be altered by ______ and particle characteristics in altered therapeutic effectiveness.

Answer 42

physical manipulation

Question 43

Process of reducing particle size with a finer state of subdivision.

Answer 43

Comminution

Question 44

determines the volume distribution of particles suspended in an electrolyte containing solution

Answer 44

Coulter counter

Question 45

TECHNIQUES IN PARTICLE SIZE DETERMINATION

Answer 45

Sieving (40 - 9500 micrometers) Coulter counter

Question 46

Drug micronization can increase dissolution rate and its bioavailability

Answer 46

Suspendability

Question 47

suspendability of particles intended to remain undissolved but uniformly dispersed in a liquid vehicle.

Answer 47

Suspendability

Question 48

Ensures dose-to-dose content uniformity

Answer 48

Uniform distribution

Question 49

drugs intended to be inhaled or positioned in the respiratory tract.

Answer 49

Penetrability

Question 50

observed in dermal ointment, creams, and ophthalmic preparations

Answer 50

Lack grittiness

Question 51

COMMINUTION TECHNIQUE

Answer 51

Milling Trituration Levigation Pulverization with intervention

Question 52

employed in a large-scale production. A mechanical process of reducing particle size before mixing with other components, product processing, or incorporation into a final product.

Answer 52

Milling

Question 53

Substance is reduced into smaller particles by rubbing it on a mortar and pestle.

Answer 53

Trituration

Question 54

The particle size of a substance is reduced by adding a suitable non-solvent levigating agent to form a paste. The paste is then rubbed using a mortar and pestle or using an ointment slab and spatula.

Answer 54

Levigation

Question 55

Substances are reduced and subdivided with an additional material- which is solvent, that can be removed easily after pulverization is complete.This

Answer 55

Pulverization with intervention

Question 56

_________ technique is applied to substances which are gummy that intend to agglomerate and resist grinding.

Answer 56

Pulverization with intervention

Question 57

Administration of fluid and electrolyte by mouth to prevent/treat dehydration due to acute diarrheal disease

Answer 57

Oral Rehydration therapy

Question 58

Normal physiologic body response to aid itself of a noxious toxic substance. Characterized by an increased frequency of loose watery stool. Can cause dehydration

Answer 58

Diarrhea

Question 59

Effective in the treatment of patients with mild volume depletion of 5-10% of Body Weight

Answer 59

Oral Rehydration Salt

Question 60

Advantages of ORS

Answer 60

OTC, Inexpensive, Diminishes incidence of complications associated with parenterally administered electrolyte solution

Question 61

is a good source of sodium, potassium, and chloride

Answer 61

Potassium chloride

Question 62

helps correct the subsequent metabolic acidosis which is cost by diarrhea and dehydration

Answer 62

Sodium chloride

Question 63

glucouse transport is coupled with sodium absorption

Answer 63

Anhydrous glucose