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LAB_Tablets Flashcards

1
Q

Tablets are obtained by compressing uniform volumes of particles or another suitable manufacturing technique like:

A

-Extrusions
-Moulding
-Freeze drying

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2
Q

An applied force causing these
raw materials to go into the dice

A

Extrusion

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3
Q

Tablets are used mainly for ___________ drug delivery and may also be used for local effect.

A

systemic

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4
Q

Compared to liquid formulations, tablets are _________ (more/less) stable chemically, physically and
microbiologically

A

More

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5
Q

Tablets have __________ bioavailability of drugs

A

poor bioavailability of drugs

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6
Q

Tablets are _________ (stable/unstable) in GIT

A

Unstable

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7
Q

the normal way

A

IMMEDIATE -RELEASE

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7
Q

T/F: Tables may cause harm in the gastrointestinal mucosa

A

T

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8
Q

CLASSIFICATION OF TABLETS
ACCORDING TO DRUG RELEASE

A

-IMMEDIATE -RELEASE
-MODIFIED-RELEASE

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9
Q

Drug is released rapidly after administration of the
drug is dissolved in liquid before intake.

A

IMMEDIATE -RELEASE

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10
Q

Example of IMMEDIATE -RELEASE

A

chewable, effervescent, sublingual, buccal

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10
Q

Most common type

A

IMMEDIATE -RELEASE

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11
Q

Liberated from the tablet sometime after
administration and released in normal rapid
after a period has elapsed.

A

Delayed- release

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12
Q

Example of Delayed- release

A

enteric-coated tablet, Voltaren

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13
Q

Delayed release can be combined with _____________ for local treatment

A

prolonged-release

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14
Q

Increased the period of drug absorption after
single administration with 2 or more pulses
release.

A

Pulsatile- release

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15
Q

Pulsatile- release are normally taken in

A

capsule

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16
Q

Drug is released slowly at a nearly constant
rate

A

Prolonged- release

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17
Q

A zero-order type of release is obtained
meaning the rate of elimination is constant
and does not depend on the concentration of
drug in the body.

A

Prolonged- release

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18
Q

Type of tablet that when taken, it’s intended to disintegrate and
dissolve for faster absorption in the gastrointestinal
tract.

A

SWALLOWED TABLETS

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19
Q

most common type of tablet,

A

SWALLOWED TABLETS

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20
Q

“Conventional or plain tablets”

A

SWALLOWED TABLETS

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21
Q

Excipients added in Swallowed Tablets

A

Filler, Diksintegrant, Binder, Glidant, Lubricant, Antiadherent

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22
Q

Are dropped in a glass water and carbon dioxide (
CO ) is liberated before intake for faster disintegration and dissolution.

A
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23
used to prevent formation of film, normally no binder, includes flavor and colorants.
Water-soluble lubricant
24
Effervescent Tablets are prepared by ___________ and _______________
direct compaction and compaction via granulation
25
EXample of Effervescent tablets
alkasol sorbifer, Berocca
26
In effervescent tablets, ___________ reacts with the bicarbonates/ carbonates they liberate carbon dioxide. It aids in faster dissolution of the tablet.
Cirtic acid and tartaric acid
27
Effervescent tablets ___________ the pH temporarily, it will cause for _____________ and will go directly to the ___________ and be absorbed there.
increases; rapid gastric emptying; small intestine
28
Chewed to facilitate quick disintegration of the tablets and absorption in gastrointestinal tract or intestine
CHEWABLE TABLETS
29
T/F: Chewable tablets can be taken when water is not available
T
30
Chewable tablets normally doesn't have __________
disintegrant
31
used as fillers in chewable tablets, has flavoring agent and colorant
Mannitol and sorbitol
32
They are attractive form of tablet and they are given to patients that have troubles in swallowing such as elderly patients and children.
CHEWABLE TABLETS
33
under the tongue
Sublingual-
34
example of. tablet that is administered sublingually
Clonidine
35
side of the cheek or between upper lip and gum the lips
Buccal
36
Buccal tablets are absorb directly by the veins which goes straight to the ____________ between the gum and front lips or cheeks. It avoids first-pass effect.
superior vena cava
37
used to to adhere (in the cheeks/ under the tongue) in place forming a gel
High molecular weight hydrophilic polymers and/ or gums,
38
__________ coated tablets are used for palatability, aesthetic appeal
Sugar coated
39
Sugar coated may take ______ - _______ coats of concentrated syrup solution
Sugar coated may take ______ - _______ coats of concentrated syrup solution
39
Pass through the stomach unaltered - release the effect within the intestinal tract
Enteric coated
40
The coating is designed to rupture and expose the core tablet at the desired location in the gastrointestinal tract.
Film coated
40
Protect the drug from destruction by gastric fluid or to aboid gastric irritation/ bypass of the gastrointestinal tract enhances drug absroption
Enteric coated
41
It will not disintegrate right away because there is a desired location wherein, it will be absorbed or disintegrated for absorption.
Film coated
42
is a capsule-shaped comparessed tablet, coated with gelatin to facilitate swallowing
Gelatin coated tablets
42
used to protect the contents from light, atmospheric oxygen, contamination and any microbial growth.
Gelatin
43
it is the process of adding lubricant to the dry granules while passing through a sieve #60-100)
Bolting
43
T/F: Gelatin can also mask the taste of unpalatable tablet.
T
44
Example of Gelatin capsule
extra Strength Tylenol PM Gelcaps
44
Upper part of mold is for
die
45
Type of granulation that uses roller compactor
Dry granulation
46
Sieve no. used in dry granulation
12
47
Sieve no. used in wet granulation
6 or 8; then 12 after dring, then #60-100 while bolting
48
Bolting is done during _______ granulation
wet
49
MOLDED TABLETS
“Tablet triturates”
50
Lower part of mold is for
punches
51
Molds are wetted with __________ mixture of ______ and ________
50%; water and alcohol
52
FILLER a.k.a ________
DILUENT
53
Tablets normally weighs at least _______ mg
50
54
Ideal filler:
- Chemically intert - Non hygroscopic - Biocompatible - Possess good biopharmaceutical and technical properties - Palatable - Reasonable cost
55
Examples of filler
Lactose, sucrose, glucose, mannitol, sorbitol, dicalcium phosphate dihydrate, calcium carbonate and cellulose
56
Promote breakup of the tablets after administration to smaller particles for ready drug availability
DISINTERGANT
57
Example of disintegrant
Starch, cellulose, cross-linked polyvinylpyrrolidone (PVP) (very common), sodium starch glycolate (SGG), sodium carboxymethylcellulose (CMC) and (Croscarmellose sodium)
58
“The glue”
BINDER (ADHESIVE)
59
Added to a fillers to ensure granules and tablets have required mechanical strength
BINDER (ADHESIVE)
60
Binders can be added as ____________ + other ingredients before wetting
Dry powder
61
Binders can be added as Solution (solution binder) glucose ________, starch paste ___________
25-50%; 10-20%
62
Dry binders
microcrystalline cellulose and cross-linked polyvinylpyrrolidone (PVP)
63
Traditional binders
starch, sucrose, gelatin
64
Modern binders
polymers like polyvinylpyrrolidone (PVP) and hydroxypropyl cellulose (HPC) cellulose derivatives - wet granulation
65
Improve flowability of the powder
66
Glidants are added to granules __________ tableting to ensure flowability
before
67
Traditional glidant
talc (1-2% by weight)
68
Modern glidant
colloidal silica (0.2% by weight)
69
can be glidant and lubricant
Magnesium stearate
70
Ensure that tablet formation and ejection can occur with low friction between the solid and the die wall
LUBRICANT
71
between moving surfaces of the solids.
Fluid lubrication
72
film lubricant.
Boundary lubrication
73
EXamples of Boundary lubrication
Stearic acid or stearic acid salts
74
Examples of lubricants
magnesiums sterate (1%), Talc 5%, stearic acid, sodium stearyl fumarate
75
Antiadherents reduce adhesion between the powder and the punch faces and thus prevent particles _________ to the punches.
sticking/ picking
76
examples of antiadherent
● Magnesium stearate - anti adherent ● Talc ● Starch ● Cellulose
77

Manuf (12 decks)

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