Act 9

Question 1

Prepared agglomerates of smaller particle size

Answer 1

Granules

Question 2

Granules are _________ shaped and behaved as a single particle

Answer 2

Irregularly

Question 3

T/F: Granules may be prepared spherical

Answer 3

T

Question 4

In the preparation of granules, we make use of sieve no.

Answer 4

sieve #4-12

Question 5

________ are preparation consisting of solvent, dry
aggregates of powder quantity sufficienty resistant
that can withstand handling.

Answer 5

Granules

Question 6

Granules are intended for

Answer 6

oral administration

Question 7

T/F: Granules are swallowed, chewed, dissolved or dispered in water or
another suitable solvent before administered to the patient.

Answer 7

T

Question 8

T/F: Granules contain one or more active substances
with or without excipients and if possible you can
add suitable colorants and flavorant substances.

Answer 8

T

Question 9

Disadvantages of Granules

Answer 9

• Particle size differences
• ingredients may segregate either in the hopper’s of the packaging machine or storage in the final bulk container.

Question 10

Granules are mainly used for ______ (low/high) toxicity, ________ (low/high)
dose drugs

Answer 10

low; high

Question 11

used as a bulk-forming laxative and has a dose of 1-4g daily.

Answer 11

methylcellulose granules

Question 12

T/F: single dose granules are enclosed in an individual container.

Answer 12

T

Question 13

Preparations containing volatile ingredients must be stored in an

Answer 13

airtight container

Question 14

Methylcellulose granules are stored in a

Answer 14

wide mouth airtight container

Question 15

uncoated granules containing acid substances
and carbonates or Hydrogen carbonates
which react rapidly in the presence of water
and release carbon dioxide.

Answer 15

Effervescent granules

Question 16

Intended to be
dissolved or dispersed in water prior to
administration

Answer 16

Effervescent

Question 17

Consists of granules coated with one or more
layers of mixtures of various excipients.

Answer 17

Coated granules

Question 18

Substances used as coatings, generally
Polymers, are usually applied as solution or
suspension in conditions in which evaporation
of the vehicle occurs leaving a film ot coating

Answer 18

Coated granules

Question 19

It is also referred to as enteric coated.

Answer 19

Gastro-resistant

Question 20

Gastro-resistant granules
are ___________granules that are intended
to resist gastric fluid release of the active
substances in the intestinal fluid.

Answer 20

delayed release

Question 21

Coated or uncoated granules that contain
special excipients or which are prepared by
special procedures both designed to modify
the rate, place, time at which the active
substances are released.

Answer 21

Modified release

Question 22

Pharmaceutical process which attempts to
convert powdered materials into aggregates

Answer 22

Granulation

Question 23

TYPES OF GRANULATION

Answer 23

Dry granulation
Wet granulation
Fluid bed granulation

Question 24

Allows granulation with or without moisture

Answer 24

Granulating machine/Granulator

Question 25

Employed in large scale manufacturing

Answer 25

Granulating machine/Granulator

Question 26

granules are formed by compacting large masses of the powder mixture and subsequently crushing it into pieces.

Answer 26

Dry granulation

Question 27

requires the drug or the diluent to have cohesive properties to form large masses.

Answer 27

Dry granulation

Question 28

Involves wetting powder mixture, sieving and drying in preparation of granules

Answer 28

Wet granulation

Question 29

A liquid binder or an adhesive is first added to the powder mixture. The moist mass is then passed through a screen of the desired mesh size and the resulting granules are dried. The dried granules can be passed through the second screen of a smaller mesh to reduce the size of the granules, even powder.

Answer 29

Wet Granulation method

Question 30

results in granules that are too hard for proper tableting.

Answer 30

Overwetting

Question 31

results to soft tablets that tends to crumble

Answer 31

Underwetting

Question 32

3rd method of granulation

Answer 32

Fluid bed granulation

Question 33

T/F: Since microparticles are considered as granules, approaches of making microparticles such as fluid bed drying technology can be used for granulation.

Answer 33

T

Question 34

A granulating solution is sprayed on to the suspended particles that are then dried rapidly in the suspending air.

Answer 34

Fluid bed granulation

Question 35

Penicillin G is also known as

Answer 35

Benzyl Penicillin

Question 36

Penicillin V is also known as

Answer 36

Phenoxymethyl

Question 37

A modified penicillin having C6H5OCH2 as radical

Answer 37

Penicillin V

Question 38

Relatively stable in the presence of gastric acidity, soluble in duodenal fluids and orally effective without buffer

Answer 38

Penicillin V

Question 39

Pharmacologic category of PHENOXYMETHYL PENICILLIN POTASSIUM GRANULES FOR ORAL SOLUTION

Answer 39

Antibacterial Anti-infective derived from natural source

Question 40

provides faster and higher blood level than phenoxymethyl penicillin

Answer 40

Oral Pen V. Potassium

Question 41

CGMP requirement of Antibacterial prep

Answer 41

Must be manufactured in a separate area from non-penicillin