Flashcards in Acute inflammation I Deck (19):
1
What type of inflammation is characteristically seen in body cavities?
Fibrinous inflammation
2
What is "organization"?
Ingrowth of fibroblasts and blood vessels if fibrin is not completely removed following fibrinous inflammation
3
At what vascular level does increased permeability take place?
Capillaries and postcapillary venules
4
What are cell adhesion molecules?
1. Membrane proteins that promote leukocyte attachment and participation in the inflammatory response 2. Selectins, Ig family, integrins
5
What are selectins?
Calcium-dependent lectins expressed on surface of endothelium, platelets, and leukocytes that serve as homing receptors and mediate ROLLING of leukocytes along endothelium at sites of inflammation
6
Are selectins involved in FIRM adhesion?
No
7
What does P-selectin recognize?
Lewis-X type oligosaccharides on surface proteins and PSGL-1
8
Where is E-selectin synthesized?
Stimulated endothelium (by TNFa or IL-1)
9
What is the function of ICAM-1?
Assists in localization of leukocytes to tissue injury
10
Where is ICAM-1 expressed?
Surface of cytokine stimulated ENDOTHELIUM
11
What does ICAM-1 bind to?
LFA-1 and Mac-1 present on cell membranes of neutrophils and macrophages
12
What does VCAM-1 bind to?
Integrin VLA-4 on lymphocytes, monocytes, eosinophils, and basophils
13
What is the function of PECAM-1 (CD31)?
Plays important role in the diapedesis step of leukocyte emigration
14
What does PECAM-1 (CD31) bind to?
CD31 of apposing cell in a homophilic manner
15
What are the functions of integrins?
Regulation of cellular matrix and cell-to-cell adhesion, linking cytoskeleton to exterior environment
16
What is the role of B1 / VLA integrins?
Binds to VCAM-1 on endothelium
17
Where are B1 / VLA integrins expressed?
Only on leukocytes
18
Where do B2 / LFA integrins bind?
ICAM-1
19