Acute inflammation I Flashcards Preview

Year 1 Pathology > Acute inflammation I > Flashcards

Flashcards in Acute inflammation I Deck (19):
1

What type of inflammation is characteristically seen in body cavities?

Fibrinous inflammation

2

What is "organization"?

Ingrowth of fibroblasts and blood vessels if fibrin is not completely removed following fibrinous inflammation

3

At what vascular level does increased permeability take place?

Capillaries and postcapillary venules

4

What are cell adhesion molecules?

1. Membrane proteins that promote leukocyte attachment and participation in the inflammatory response 2. Selectins, Ig family, integrins

5

What are selectins?

Calcium-dependent lectins expressed on surface of endothelium, platelets, and leukocytes that serve as homing receptors and mediate ROLLING of leukocytes along endothelium at sites of inflammation

6

Are selectins involved in FIRM adhesion?

No

7

What does P-selectin recognize?

Lewis-X type oligosaccharides on surface proteins and PSGL-1

8

Where is E-selectin synthesized?

Stimulated endothelium (by TNFa or IL-1)

9

What is the function of ICAM-1?

Assists in localization of leukocytes to tissue injury

10

Where is ICAM-1 expressed?

Surface of cytokine stimulated ENDOTHELIUM

11

What does ICAM-1 bind to?

LFA-1 and Mac-1 present on cell membranes of neutrophils and macrophages

12

What does VCAM-1 bind to?

Integrin VLA-4 on lymphocytes, monocytes, eosinophils, and basophils

13

What is the function of PECAM-1 (CD31)?

Plays important role in the diapedesis step of leukocyte emigration

14

What does PECAM-1 (CD31) bind to?

CD31 of apposing cell in a homophilic manner

15

What are the functions of integrins?

Regulation of cellular matrix and cell-to-cell adhesion, linking cytoskeleton to exterior environment

16

What is the role of B1 / VLA integrins?

Binds to VCAM-1 on endothelium

17

Where are B1 / VLA integrins expressed?

Only on leukocytes

18

Where do B2 / LFA integrins bind?

ICAM-1

19

What is the role of B2 / LFA integrins?

Assist in localization of phgocytes to injury sites and subsequent extravasation