Chronic inflammation I Flashcards Preview

Year 1 Pathology > Chronic inflammation I > Flashcards

Flashcards in Chronic inflammation I Deck (8)
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1

Which cell type is responsible for most of the tissue injury in chronic inflammation?

Macrophages

2

What are some macrophage activation signals?

Cytokines from T cells (Th1) and NK cells, endotoxin, other chemical mediators

3

Large, multinucleated giant cells can be produced through fusion of macrophages caused by what cytokines?

IL-4 and IFNy

4

Recruitment of eosinophils depends on what chemokine?

Eotaxin

5

Eosinophil granules contain what protein?

Major basic protein

6

What are the features of major basic protein?

Highly cationic, toxic to parasites, causes epithelial cell lysis

7

Mast cells release which cytokines?

Histamine, PG, TNF

8

Mast cell activation leads to what changes in the vasculature?

Increased permeability and vasoconstriction