Flashcards in Chronic inflammation I Deck (8)
Which cell type is responsible for most of the tissue injury in chronic inflammation?
What are some macrophage activation signals?
Cytokines from T cells (Th1) and NK cells, endotoxin, other chemical mediators
Large, multinucleated giant cells can be produced through fusion of macrophages caused by what cytokines?
IL-4 and IFNy
Recruitment of eosinophils depends on what chemokine?
Eosinophil granules contain what protein?
Major basic protein
What are the features of major basic protein?
Highly cationic, toxic to parasites, causes epithelial cell lysis
Mast cells release which cytokines?
Histamine, PG, TNF