Flashcards in Cellular adaptations and accumulations II Deck (15)
What are the three categories of intracellular accumulations?
1. Normal substance produced at increased rate - inadequate removal 2. Normal or abnormal substance accumulates - genetic 3. Abnormal exogenous substance deposited - cannot be removed
What are atheromas?
Cholesterol laden aggregates found in the intimal layer of the aorta and large arteries - filled with lipid vacuoles
What are cholesterol clefts?
Extracellular crystallizations formed from lipids released from ruptured foam cells
What are Russell bodies?
Accumulations of antibodies within plasma cells
What are Mallory bodies?
Eosinophilic intracytoplasmic inclusions composed of cytoskeletal kertain filaments; characteristically seen in alcoholic liver disease
What are examples of intracellular hyaline change?
Protein droplets in renal tubules, Russell bodies, Mallory alcoholic hyalin, viral inclusions
What are examples of extracellular hyaline change?
Collagenized scar, damaged glomeruli, hyaline arteriosclerosis, atherosclerosis, amyloid
Hemosiderin is derived from what molecule?
Intracellular storage of iron is via what molecule?
What molecule is responsible for forming hemosiderin granules during local or systemic iron excess?
What do hemosiderin pigments represent?
Does bilirubin contain iron?
What are serum calcium levels like during dystrophic calcification?
What are serum calcium levels like during metastatic calcification?