Cellular adaptations and accumulations II Flashcards Preview

Year 1 Pathology > Cellular adaptations and accumulations II > Flashcards

Flashcards in Cellular adaptations and accumulations II Deck (15)
Loading flashcards...
1

What are the three categories of intracellular accumulations?

1. Normal substance produced at increased rate - inadequate removal 2. Normal or abnormal substance accumulates - genetic 3. Abnormal exogenous substance deposited - cannot be removed

2

What are atheromas?

Cholesterol laden aggregates found in the intimal layer of the aorta and large arteries - filled with lipid vacuoles

3

What are cholesterol clefts?

Extracellular crystallizations formed from lipids released from ruptured foam cells

4

What are Russell bodies?

Accumulations of antibodies within plasma cells

5

What are Mallory bodies?

Eosinophilic intracytoplasmic inclusions composed of cytoskeletal kertain filaments; characteristically seen in alcoholic liver disease

6

What are examples of intracellular hyaline change?

Protein droplets in renal tubules, Russell bodies, Mallory alcoholic hyalin, viral inclusions

7

What are examples of extracellular hyaline change?

Collagenized scar, damaged glomeruli, hyaline arteriosclerosis, atherosclerosis, amyloid

8

Hemosiderin is derived from what molecule?

Hemoglobin

9

Intracellular storage of iron is via what molecule?

Hemosiderin

10

What molecule is responsible for forming hemosiderin granules during local or systemic iron excess?

Ferritin

11

What do hemosiderin pigments represent?

Ferritin micelles

12

Does bilirubin contain iron?

No

13

What are serum calcium levels like during dystrophic calcification?

Normal

14

What are serum calcium levels like during metastatic calcification?

Elevated

15

What is the end product of dystrophic calcification?

Crystalline calcium phosphate