Acute Leukemias

Question 1

ALL cases more frequently involve _____ cells (~80%).

Answer 1

B

Question 2

__-ALL is more commonly seen in adolescents and young adults.

Answer 2

T

Question 3

__-ALL is more commonly seen in children.

Answer 3

B

Question 4

__-ALL is more commonly seen in men than women

Answer 4

T

Question 5

__-ALL is more likely to present with a large mediastinal mass.

Answer 5

T

Question 6

B-ALL has a ______ prognosis than T-ALL.

Answer 6

better

Question 7

B-ALL is more commonly seen in _____ (demographic).

Answer 7

children

Question 8

Cytogenetic abnormalities associated with AML due to CBFB-MYH11

Answer 8

inv(16)(p13.1;q22) or t(16;16)(p13.1;q22)

Question 9

Cytogenetic abnormality associated with a poor prognosis AML

Answer 9

11q23 MLL

Question 10

Cytogenetic abnormality associated with AML due to RNX1-RNX1T1

Answer 10

t(8;22)(q22;q22)

Question 11

Cytogenetic abnormality associated with AML with megakaryoblastic differentiation

Answer 11

t(1;22)(p13;q13), RBM15-MKL1

Question 12

Cytogenetic abnormality associated with APML

Answer 12

t(15;17)(q22q22)

Question 13

Cytogenetic abnormality most often seen in infants with Down Syndrome

Answer 13

t(1;22)(p13;q13), RBM15-MKL1

Question 14

Cytogenetic finding associated with AML with monocytic differentiation

Answer 14

11q23 MLL

Question 15

Cytogenetic finding associated with B-ALL in neonates and young infants

Answer 15

11q23 MLL

Question 16

Cytogenetic finding associated with the worst prognosis of any ALL

Answer 16

T(9;22)(q34;q11.2), BCR-ABL

Question 17

Cytogenetic finding with B-ALL with a very favorable prognosis

Answer 17

t(12;21)(p13;q22), ETV6-RUNX1

Question 18

Findings to diagnose AML (2)

Answer 18

Myeloblasts >20% of nucleated cells in marrow or peripheral blood, cytogenetic findings

Question 19

Fused azurophilic granules that form small stick-like structures in the cytoplasm

Answer 19

Auer Rods

Question 20

Genes associated with AML cases seen in younger patients with relatively good prognosis?

Answer 20

RNX1, CBFB

Question 21

How is ALL prognosis affected by age?

Answer 21

Worst in infants, older children, or adults

Question 22

How is ALL prognosis affected by chromosome ploidy?

Answer 22

Hyperdiploidy is associated with better prognosis

Question 23

How is ALL prognosis affected by response to therapy?

Answer 23

Slow response is worse prognosis

Question 24

How is ALL prognosis affected by T vs. B ALL?

Answer 24

B-ALL has better prognosis

Question 25

How is ALL prognosis affected by WBC count?

Answer 25

Worse for higher count

Question 26

Molecular markers currently used to predict prognosis in patients with AML with normal karyotype (3)

Answer 26

FLT3 ITD, NPM1, CEBPA

Question 27

Negative prognostic factor associated with normal karyotype AML

Answer 27

FLT3 ITD

Question 28

Potential complication of t(15;17)(q22;q22)

Answer 28

DIC

Question 29

Prognosis of t-AML

Answer 29

Very poor

Question 30

T-ALL has a _____ prognosis than B-ALL.

Answer 30

worse

Question 31

T-ALL is more commonly seen in _____ (demographic).

Answer 31

adolescents and young adults

Question 32

t-AML with complex karyotype, frequently whole or partial loss of chromosomes 5 or 7

Answer 32

Secondary to alkylating agents or radiation

Question 33

t-AML with latency 1-2 years

Answer 33

Secondary to Topoisomerase II inhibitors

Question 34

t-AML with latency 2-8 years

Answer 34

Secondary to alkylating agents or radiation

Question 35

t-AML with rearrangement of MLL gene

Answer 35

Secondary to Topoisomerase II inhibitors

Question 36

Therapy-related AML with an MDS stage

Answer 36

Secondary to alkylating agents or radiation

Question 37

Treatment for t(15;17)(q22;q22)

Answer 37

All-Trans Retinoic Acid (ATRA) with arsenic salts

Question 38

Type of acute leukemia and prognosis? t(15;17)(q22;q22)

Answer 38

Acute Promyelocytic Leukemia; best remission rates for AML

Question 39

Type of ALL and prognosis? 11q23/MLL

Answer 39

B-ALL, poor

Question 40

Type of ALL and prognosis? t(12;21)(p13;q22), ETV6-RUNX1

Answer 40

B-ALL, very good

Question 41

Type of ALL and prognosis? T(9;22)(q34;q11.2), BCR-ABL

Answer 41

B-ALL, worst of all ALL

Question 42

Types of therapy-related AML

Answer 42

Secondary to alkylating agents or radiation, Secondary to Topoisomerase II inhibitors

Question 43

What feature can be used to distinguish abnormal myeloblasts?

Answer 43

Auer Rods

Question 44

Which acute leukemia shows predomination of promyelocytes?

Answer 44

Acute Promyelocytic Leukemia; best remission rates for AML