CBC, Peripheral Blood and Marrow, and Hematopoiesis

Question 1

____ stimulates basophil production

Answer 1

IL-3

Question 2

____ stimulates eosinophil production

Answer 2

IL-5

Question 3

_______ are anucleate cells in the erythroid lineage

Answer 3

reticulocytes and erythrocytes

Question 4

_______ lineage: _______ -> basophilic normoblast -> polychromatophilic normoblast -> orthochromatic normoblast -> _______ -> _______

Answer 4

Erythroid; Pronormoblast; reticulocyte; erythrocytes

Question 5

_______ lineage: Myeloblast -> promyelocyte -> myelocyte -> metamyelocyte -> ______ -> ______

Answer 5

Granulocyte; band; segmented —–phil

Question 6

A pale blue inclusion at the periphery of a RBC consisting of condensed RNA is described as _______

Answer 6

Dohle Body

Question 7

Average lifetime of erythrocytes in the peripheral blood

Answer 7

120 days

Question 8

Average lifetime of monocytes in the peripheral blood before becoming macrophages in tissues

Answer 8

20 days

Question 9

Average lifetime of neutrophils in the peripheral blood

Answer 9

7-10 hours

Question 10

Average lifetime of platelets in the peripheral blood

Answer 10

8-9 days

Question 11

Childhood levels of HGB and HCT are _______ than those of adults

Answer 11

lower

Question 12

Denatured/oxidized hemoglobin attached to the inner side of the cell membrane is described as _______.

Answer 12

Heinz Bodies

Question 13

Erythroid lineage: _______ -> basophilic normoblast -> _______ -> orthochromatic normoblast -> reticulocyte -> erythrocytes

Answer 13

Pronormoblast; polychromatophilic normoblast

Question 14

Erythroid lineage: Pronormoblast -> _______ -> polychromatophilic normoblast -> orthochromatic normoblast -> _______ -> erythrocytes

Answer 14

basophilic normoblast; reticulocyte

Question 15

Erythroid lineage: Pronormoblast -> _______ normoblast -> _______ normoblast -> _______ normoblast -> reticulocyte -> erythrocytes

Answer 15

basophilic; polychromatophilic; orthochromatic

Question 16

Female HCT

Answer 16

36-47%

Question 17

Female normal concentration of RBCs

Answer 17

4.2-5.6x10^12/L

Question 18

Female normal HGB

Answer 18

12.1-16.3g/L

Question 19

Granulocyte lineage: _______ -> promyelocyte -> myelocyte -> metamyelocyte -> _______ -> segmented —–phil

Answer 19

Myeloblast; band

Question 20

Granulocyte lineage: Myeloblast -> _______ -> myelocyte -> _______ -> band -> segmented —–phil

Answer 20

promyelocyte; metamyelocyte

Question 21

IL-3 stimulates ______ production

Answer 21

basophil

Question 22

IL-5 stimulates _______ production

Answer 22

eosinophil

Question 23

In bone marrow, the ratio of granulocytic:erythroid precursors should be about ____.

Answer 23

3 to 1

Question 24

In the erythroid lineage, the ability to replicate is lost at progession to the _______ stage.

Answer 24

Orthochromic normoblasts

Question 25

In the granulcyte lineage, the last cell with replicative ability is the _______

Answer 25

myelocyte

Question 26

In the granulocyte lineage, primary granules first appear in the ______ stage.

Answer 26

promyelocyte

Question 27

In the granulocyte lineage, the largest cell is the _____

Answer 27

promyelocyte

Question 28

In the megakaryocyte lineage, endoreduplication begins in the _____ stage.

Answer 28

promegakaryocyte

Question 29

Male HCT

Answer 29

39-50%

Question 30

Male Normal concentration of RBCs

Answer 30

4.75-6.1x10^12/L

Question 31

Male normal HGB

Answer 31

14.3-18.1g/L

Question 32

Megakaryocyte lineage: _______ -> _______ -> megakaryocyte -> platelet

Answer 32

megakaryoblast; promegakaryoctye

Question 33

Men have _______ HGB and HCT than women

Answer 33

higher

Question 34

Menstruating and pregnant women have _______ HGB and HCT

Answer 34

lower

Question 35

Monocyte lineage: _______ -> _______ -> monocyte

Answer 35

monoblast; promonocyte

Question 36

Normal Basophil %

Answer 36

0-2%

Question 37

Normal Eosinophil %

Answer 37

0-6%

Question 38

Normal Lymphocyte %

Answer 38

20-50

Question 39

Normal MCH

Answer 39

27.5-35pg

Question 40

Normal MCHC

Answer 40

32-36g/L

Question 41

Normal MCV

Answer 41

80-100fL

Question 42

Normal Monocyte %

Answer 42

2-11%

Question 43

Normal Neutrophil %

Answer 43

40-72

Question 44

Normal Platelet Count

Answer 44

150-400x10^9/L

Question 45

Normal Reticulocyte %

Answer 45

0.4-1.7%

Question 46

Normal WBC Count

Answer 46

4.0-11.1x10^9/L

Question 47

Nuclear DNA remnants that appear as single, dense, blue dot can be described as_______.

Answer 47

Howell-Jolly Bodies

Question 48

RI<1 with anemia indicates _______ production of RBCs

Answer 48

decreased

Question 49

RI>2 with anemia indicates ______ production of RBCs

Answer 49

increased

Question 50

The largest blood cell is a _______.

Answer 50

monocyte

Question 51

This blood cell has a large kidney-shaped nucleus

Answer 51

monocyte

Question 52

What is the function of erythropoietin? In what organ is it made?

Answer 52

Promote erythropoiesis; kidney

Question 53

What is the function of thrombopoietin?

Answer 53

Promote production of megakaryocytes

Question 54

When aggregated ribosomes are present in RBCs, they appear as _____.

Answer 54

basophilic stippling