Hemoglobin, Hemoglobinopathies, and Thalassemia Flashcards Preview

Blood and Lymph > Hemoglobin, Hemoglobinopathies, and Thalassemia > Flashcards

Flashcards in Hemoglobin, Hemoglobinopathies, and Thalassemia Deck (29)
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1
Q

____ has two alpha chains and two delta chains

A

HbA2

2
Q

____ has two alpha chains and two epsilon chains

A

Hb Gower II

3
Q

____ has two alpha chains and two gamma chains

A

HbF

4
Q

____ has two zeta chains and two epsilon chains

A

Hb Gower

5
Q

____ has two zeta chains and two gamma chains

A

Hb Portland

6
Q

_____ induces production of fetal hemoglobin

A

hydroxyurea

7
Q

______ consists of four beta chains

A

HbH

8
Q

______ consists of four gamma chains

A

Hb Barts

9
Q

______ is an important cause of aplastic crisis in children.

A

Parvovirus B19

10
Q

2,3-BPG stabilizes hemoglobin in the ____ conformation

A

T

11
Q

As 2,3-BPG increases, oxygen affinity _____ (____ shift)

A

decreases; right

12
Q

As carbon dioxide concentration increases, oxygen affinity ____ (___ shift)

A

decreases; right

13
Q

As pH increases, oxygen affinity _____ (___ shift)

A

increases; left

14
Q

As temperature increases, oxygen affinity _____ (___ shift)

A

decreases; right

15
Q

Extramedullary erythropoiesis and frontal bossing are associated with ______.

A

Thalassemia

16
Q

Hydrops fetalis is most likely to occur in offspring of ______ descent.

A

Asian

17
Q

In sickle cell anemia, bilirubin, LDH, and AST are _____.

A

increased

18
Q

In sickle cell anemia, platelet count is _____.

A

increased

19
Q

In sickle cell anemia, reticulocytes count is _____.

A

increased

20
Q

In sickle celll anemia, RDW is _____.

A

increased

21
Q

In thalassemia, bilirubin, LDH, and AST are _____.

A

increased

22
Q

In thalassemia, MCV is ______.

A

decreased

23
Q

In thalassemia, reticulocyte count is _____.

A

increased

24
Q

Methemoglobinemia results in a ____ shift on the hemoglobin binding curve

A

left

25
Q

Oxidation of Iron (II) to Iron (III) converts hemoglobin into ______.

A

methemoglobin

26
Q

The high affinity conformation is the ___ conformation

A

R

27
Q

The low affinity conformation is the ___ conformation

A

T

28
Q

What condition is characterized by dark, chocolate covered blood?

A

Methemoglobinemia

29
Q

What condition is characterized by headache, malaise, nausea, dizziness; can even have seizures, coma, or myocardial infarction or late neurologic deficits (cognition loss, personality change, movement disorders)?

A

Carbon Monoxide poisoning