Flashcards in Adrenal Pathology Deck (40):
What three disorders of the adrenal gland cause too much hormones?
What tests are used to diagnose Cushing Syndrome?
24 hour urine free cortisol
Loss of normal diurnal cortisol secretion
Dexamethasone suppression test
What is the most common cause of Cushing syndrome?
What do Cortisol/ACTH tests look like for Iatrogenic Cushing Syndrome?
What is the most common endogenous cause of Cushing syndrome?
What do Cortisol/ACTH levels look like for Cushing Disease?
What happens to cortisol levels with a high-dose dexa test in Cushing disease?
What are causes of adrenal cushing syndrome?
Adenoma, hyperplasia, carcinoma
What are Cortisol/ACTH levels for Adrenal Cushing Syndrome?
What happens to cortisol levels with a high-dose dexa test in Adrenal cushing syndrome?
What is the most common cause of paraneoplastic cushing syndrome?
SCC of the lung
What are Cortisol/ACTH levels for paraneoplastic Cushing syndrome?
Increased ACTH (fake)
What happens to cortisol levels with a high-dose dexa test in paraneoplastic Cushing syndrome?
What are the main effects of aldosterone?
Retain Na and H2O
Pee out K
What are symptoms of hyperaldosteronism?
Hypokalemia (weakness, fatigue, psychosis)
What are common lab findings of primary hyperaldosteronism?
What are the most common causes of primary hyperaldonism?
Cortical adenoma (Conn Syndrome)
What are the common causes of secondary hyperaldosteronism?
Anything that increases renin
Decreased renal blood flow
Renin producing tumors
What are the lab findings of secondary hyperaldosteronism?
Same as primary with HIGH renin
If you have a patient with SUDDEN virilization, what is likely the problem?
What does adrenocortical carcinoma look like grossly?
Necrotic, ugly tumor
What's the prognosis like for adrenocortical carcinoma?
What's the most common cause of congenital adrenal hyperplasia?
What is the result of 21 hydroxylase deficiency?
Decreased cortisol and aldosterone
Increased sex steroids
What is Addison disease?
Primary chronic adrenal insufficiency
What is the cause of Addison disease?
What are symptoms of Addison disease?
Weakness, fatigue, GI complaints
What are causes of primary acute adrenal insufficiency?
Rapid steroid withdrawal
Massive adrenal hemorrhage
When do you see massive adrenal hemorrhage?
Neisseria infection in an infant
What is Waterhouse-Friderichsen syndrome?
The neisseria infection of an infant
What does Waterhouse Friderichsen syndrome look like?
Massive bilateral adrenal hemorr.
What are the most common causes of secondary adrenal insufficiency?
Pituitary or hypothalmic insufficiency
Tumor, infection, radiation, infarction
What does secondary adrenal insufficiency look like?
Symptoms of decreased cortisol and decreased sex steroids
Mineralocorticoids normal because Renin axis is intact
What are the 10%'s of a Pheochromocytoma?
10% (or more) familial
10% don't have hypertension
What is a pheochromocytoma?
Neoplasm of catecholamine producing cells
What do you look for in the urine if you suspect pheochromocytoma?
What are symptoms of pheochromocytoma?
Pressure (BP inc)
More copies of this gene cause a worse prognosis in neuroblastoma.
Who commonly gets neuroblastomas?