Flashcards in Parathyroid Pathology Deck (18):
What are the actions of PTH?
Increase Bone resorption
Increase Renal resorption of Ca
Increase Renal excretion of P
Increase Renal conversion of VitD to active form
Increase Gut absorption of Ca
If you have decreased serum calcium, what happens to PTH synthesis?
What are five causes of hypercalcemia?
Malignancy (mets, PTH related protein)
Vitamin D overdose
What is the most common cause of symptomatic hypercalcemia?
What is the most common cause of asymptomatic hypercalcemia?
What is secondary hyperparathyroidism due to?
Chronic hypocalcemia (renal failure)
What is tertiary hyperparathyroidism due to?
What is pseudohyperparathyroidism?
PTH-related protein from a paraneoplastic syndrome
What are the most common causes of hyperparathyroidism?
What are the signs and symptoms of hyperparathyroidism?
Bones (Pain, brown tumors)
Groans (GI Problems)
Moans (Mental changes)
What are the lab findings in primary hyperparathyroidism?
What are brown tumors?
Microhemorrhages in bone and blood just kinda sits there
What two receptors are implicated in osteoclast stimulation?
What are the common genetic defects leading to parathyroid adenoma?
PRAD 1 overexpression (Cyclin D1)
MEN1 loss or mutation
How is parathyroid carcinoma different from adenoma in clinical presentation?
Carcinoma: Abrupt onset of bone pain
What are the common causes of secondary hypoparathyroidism?
Diet poor in calcium
Low vitamin D
What are the most common causes of hypoparathyroidism?
Hereditary (DiGeorge syndrome or agenesis)