Thyroid Neoplasms Flashcards Preview

HRM - Pathology > Thyroid Neoplasms > Flashcards

Flashcards in Thyroid Neoplasms Deck (21):
1

What factors increase likelihood of malignancy?

Male
Solitary
Nodule is Cold
History of radiation

2

What cells will be seen on a slide if a fine needle aspiration is done for Hashimoto Thyroiditis?

Hurthle cells

3

If you just see follicle cells in the nodule, what are the two possibilities?

Cancer or just regular follicles

4

What is the most common neoplasm for thyroid cancer?

Adenoma

5

What are clinical symptoms for thyroid adenoma?

Most patients are euthyroid
Some hyperthyroid

6

What are lab test usually for thyroid adenoma?

TSH and T4 normal
Most adenomas "cold"

7

What is the usual morphology for thyroid adenoma?

Solitary
Encapsulated
No invasion

8

What is the usual mutation for thyroid adenoma

G-protein mutation
Gain of function mutation

9

What do you do if you see adenoma on a thyroid bx?

Take it out. Need the whole capsule to tell the two apart

10

What are the four types of thyroid carcinoma in order of decreasing prevalence?

Papillary (80%)
Follicular (10%)
Medullary (5%)
Anaplastic (<5%)

11

Who is most likely to get papillary thyroid carcinoma?

Female in 30s-50s

12

What is the prognosis for Papillary Thyroid Carcinoma?

Excellent (>95% 10y survival)

13

"Orphan Annie eye nuclei"

Papillary carcinoma

14

Who is most likely to get follicular thyroid carcinoma?

Female in 40s-50s

15

Where do follicular thyroid carcinomas usually spread?

Lung or bone

16

What are signs of worsening prognosis for follicular thyroid carcinoma?

Older person
Tumor size increase
Invasiveness

17

Who is most likely to get medullary thyroid carcinoma?

Female in 50s-60s

18

What is mutated in medullary thyroid carcinoma?

C cells

19

A bunch of amyloid?

Medullary carcinoma

20

Bulky, fast-growing, invasive neck mass

Anaplastic thyroid carcinoma

21

Who is most common to get anaplastic thyroid carcinoma?

Female in 50s-60s