Flashcards in Thyroid Neoplasms Deck (21):
What factors increase likelihood of malignancy?
Nodule is Cold
History of radiation
What cells will be seen on a slide if a fine needle aspiration is done for Hashimoto Thyroiditis?
If you just see follicle cells in the nodule, what are the two possibilities?
Cancer or just regular follicles
What is the most common neoplasm for thyroid cancer?
What are clinical symptoms for thyroid adenoma?
Most patients are euthyroid
What are lab test usually for thyroid adenoma?
TSH and T4 normal
Most adenomas "cold"
What is the usual morphology for thyroid adenoma?
What is the usual mutation for thyroid adenoma
Gain of function mutation
What do you do if you see adenoma on a thyroid bx?
Take it out. Need the whole capsule to tell the two apart
What are the four types of thyroid carcinoma in order of decreasing prevalence?
Who is most likely to get papillary thyroid carcinoma?
Female in 30s-50s
What is the prognosis for Papillary Thyroid Carcinoma?
Excellent (>95% 10y survival)
"Orphan Annie eye nuclei"
Who is most likely to get follicular thyroid carcinoma?
Female in 40s-50s
Where do follicular thyroid carcinomas usually spread?
Lung or bone
What are signs of worsening prognosis for follicular thyroid carcinoma?
Tumor size increase
Who is most likely to get medullary thyroid carcinoma?
Female in 50s-60s
What is mutated in medullary thyroid carcinoma?
A bunch of amyloid?
Bulky, fast-growing, invasive neck mass
Anaplastic thyroid carcinoma