Gyn Pathology I Flashcards Preview

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Flashcards in Gyn Pathology I Deck (36):
1

What are indicated in classic white vulvar dermatoses?

Lichen simplex
Lichen sclerosis

2

What is a hidradenoma?

benign labia neoplasm which may ulcerate (ectopic breast tissue)

3

What are most cases of malignant vulvar diseases?

Squamous cell carcinoma

4

What are most SCC's of the vulva from? What is second most common?

Most common: HPV
Second: Chronic irritation from lichen stuff

5

What other cancer non-squamous cancers can appear in the vulva?

Melanoma
Basal cell carcinoma

6

What vulvar disease consists of malignant cells that may or may not be associated with breast cancer?

Extra-mammary paget's disease

7

What nodes do the vulvar carcinomas spread to?

Inguinal/femoral nodes

8

When you have cancer in the vagina, usually what is it?

From other sources

9

What embryonal cancer is unique to the vagina?

Embryonal rhabdomyosarcoma

10

"grapelike"

rhabdomyosarcoma

11

What are the most common gynocological cancers worldwide?

Cervical carcinoma
Ovarian
Endometrial

12

How long does it take for the initial infection to become invasive CA for HPV?

15 years

13

What other cancer, other than carcinoma, can be caused by HPV in the cervix?

Adenocarcinoma (glandular)

14

Multinucleated cells on pap smear

Herpes

15

Faint odd cells

Trichomonas

16

Clue cells

Gardnerella

17

What glandular cell abnormalities can you see on pap?

Atypical glandular cells of undetermined significance
Adenocarcinoma

18

What are the two major concerns for abnormal uterine bleeding?

Anemia
Endometrial cancer

19

What are indications for endometrial biopsy?

If older than 45 do it
If younger, unopposed estrogen exposure, failed med management, tamoxifen, lynch

20

What are the main considerations for reproductive aged women?

Dysfunctional bleeding
Pregnancy
Anatomic lesions
Inherited or acquired hemostasis disorders

21

What are the symptoms for PCOS?

Oligomenorrhea
Hyperandrogenism
Obesity
Insulin resistance

22

What hormone often lacks in anovulation?

Progesterone

23

What are the most common causes of postmenopausal vaginal bleeding?

Endometrial atrophy (59%)
Endometrial polyps (12%)
Endometrial hyperplasia (10%)
Endometrial carcinoma (10%)

24

What is the average age at diagnosis for endometrial carcinoma?

61 yrs

25

What is the most common type of endometrial cancer?

Type 1 carcinoma

26

What hormone is implicated in causing type 1 carcinoma of the endometrium?

Estrogen

27

What gene is often mutated in type 1 carcinoma of the endometrium?

PTEN

28

What is type 2 endometrial carcinoma?

Serous/clear cell carcinoma

29

What cancer is Type 2 EC like?

Ovarian cancer

30

Which Endometrial carcinoma is worse?

Type 2 is much worse

31

What long term effect must be thought of with Endometrial stromal neoplasia?

Decades later metastases (esp. lung)

32

If endometrial cancer is in patients younger than 45, what genetic disorder must be assumed?

Lynch syndrome

33

Where are most common sites for endometriosis?

Pelvis (tubes, ovaries, serosa)

34

What are clinical symptoms of endometriosis?

Pelvic pain/dysmenorrhea with cyclic symptoms
Infertility

35

How is diagnosis of endometriosis done?

Laparoscopy finding punctuate surface lesions, usually blue/black/brown

36

How do you treat endometriosis?

Hormonal manipulation
Lappy ablation
Salpingooophrectomy/hysterectomy