Flashcards in Gyn Pathology I Deck (36):
What are indicated in classic white vulvar dermatoses?
What is a hidradenoma?
benign labia neoplasm which may ulcerate (ectopic breast tissue)
What are most cases of malignant vulvar diseases?
Squamous cell carcinoma
What are most SCC's of the vulva from? What is second most common?
Most common: HPV
Second: Chronic irritation from lichen stuff
What other cancer non-squamous cancers can appear in the vulva?
Basal cell carcinoma
What vulvar disease consists of malignant cells that may or may not be associated with breast cancer?
Extra-mammary paget's disease
What nodes do the vulvar carcinomas spread to?
When you have cancer in the vagina, usually what is it?
From other sources
What embryonal cancer is unique to the vagina?
What are the most common gynocological cancers worldwide?
How long does it take for the initial infection to become invasive CA for HPV?
What other cancer, other than carcinoma, can be caused by HPV in the cervix?
Multinucleated cells on pap smear
Faint odd cells
What glandular cell abnormalities can you see on pap?
Atypical glandular cells of undetermined significance
What are the two major concerns for abnormal uterine bleeding?
What are indications for endometrial biopsy?
If older than 45 do it
If younger, unopposed estrogen exposure, failed med management, tamoxifen, lynch
What are the main considerations for reproductive aged women?
Inherited or acquired hemostasis disorders
What are the symptoms for PCOS?
What hormone often lacks in anovulation?
What are the most common causes of postmenopausal vaginal bleeding?
Endometrial atrophy (59%)
Endometrial polyps (12%)
Endometrial hyperplasia (10%)
Endometrial carcinoma (10%)
What is the average age at diagnosis for endometrial carcinoma?
What is the most common type of endometrial cancer?
Type 1 carcinoma
What hormone is implicated in causing type 1 carcinoma of the endometrium?
What gene is often mutated in type 1 carcinoma of the endometrium?
What is type 2 endometrial carcinoma?
Serous/clear cell carcinoma
What cancer is Type 2 EC like?
Which Endometrial carcinoma is worse?
Type 2 is much worse
What long term effect must be thought of with Endometrial stromal neoplasia?
Decades later metastases (esp. lung)
If endometrial cancer is in patients younger than 45, what genetic disorder must be assumed?
Where are most common sites for endometriosis?
Pelvis (tubes, ovaries, serosa)
What are clinical symptoms of endometriosis?
Pelvic pain/dysmenorrhea with cyclic symptoms
How is diagnosis of endometriosis done?
Laparoscopy finding punctuate surface lesions, usually blue/black/brown