Adrenergic pharm-Pechnick Flashcards Preview

Neuro Final > Adrenergic pharm-Pechnick > Flashcards

Flashcards in Adrenergic pharm-Pechnick Deck (24):
1

What are the 5 steps in the life cycle of catecholamines (adrenergic transmission)?

1. Synthesis
2. Storage
3. Release
4. Receptor interactions
5. Termination of action

2

What is the rate limiting step in the life cycle of catecholamines?

Tyrosine hydroxylation

3

What do a1 adrenergic receptors do?

- Contraction (smooth muscle)

4

What do B1 adrenergic receptors do?

- Stimulates renin release

5

What do B2 adrenergic receptors do?

- Relaxation (smooth muscle)
- Bronchodilation

6

Epinephrine

- Agonist at B1, B2, a1, a2
- At low doses B predominates (vasodilation)
- At high doses a1 predominates (vasoconstriction)

7

Norepinephrine

- Agonist at a1, a2, B1
- Causes vasoconstriction

8

Dopamine

- Agonist at D1, B1, a1, a2
- Low/med dose: increases renal blood flow
- High dose: vasoconstriction

9

How do indirect acting sympathomimetics work?

Increase synaptic levels of neurotransmitters by inducing neurotransmitter release and/or blocking reuptake

10

Amphetamine

- Indirect sympathomimetic
- Releases NE and blocks reuptake of NE, dopamine and serotonin

11

Cocaine

- Indirect sympathomimetic
- Blocks reuptake of NE, dopamine and serotonin

12

What is the party food effect?

When people who are taking MAOB inhibitors eat a "party food" (cheese, wine, sour cream, etc.) they get fatal hypertension due to tyramine in food being broken down into MAOA

13

Ephedrine and Pseudoephedrine

- Direct weak agonist at a and B receptors
- Indirectly causes release of NE

14

Milodrine and Metaraminol

- Direct acting a1 agonists

15

Phenylephrine

- Selective a1 agonist

16

Oxymetazoline and Tetrahydrozoline

- Partial a2 agonist with some a1 agonist activity
- Eye drops (constrict eye vessels to decrease redness)

17

Clonidine

- CENTRALLY ACTING (on the brain)
- Direct a2 agonist
- Inhibits sympathetic outflow
- Decreases HR, cardiac output and peripheral resistance
- Abrupt withdrawal can cause hypertensive crisis, tachycardia and arrhythmias

18

Phentolamine and Phenoxybenzamine

- Non-selective a receptor antagonists

19

Prazosin

- Selective a1 receptor antagonist

20

Isoproterenol and Dobutamine

- B1/B2 receptor agonist
- Cardiac stimulants

21

Albulterol and Salmeterol

- Selective B2 agonist
- Asthma meds

22

Mirabegron

- B3 agonist
- Used for treatment of overactive bladder

23

Propanolol, Nadolol, Carvedilol, Labetalol, Timolol and Carteolol

- Non-selective B antagonists
- Uses: MI, CHF, arrhythmias, migraine, anxiety

24

Atenolol and Metoprolol

- Selective B1 antagonists