Anti-Epileptic Pharm-Kisby Flashcards Preview

Neuro Final > Anti-Epileptic Pharm-Kisby > Flashcards

Flashcards in Anti-Epileptic Pharm-Kisby Deck (24):
1

Which classes of drugs are ion channel inhibitors and openers?

1. Na+ channel
2. Ca2+ channel
3. K+ channel

2

Which classes of drugs enhance GABA neurotransmission?

1. GABAa receptor agonists
2. GABA uptake inhibitors
3. GABA transaminase inhibitors
4. Glutamate decarboxylase activation

3

Which class of drugs reduce glutamate neurotransmission?

Glutamate receptors antagonists

4

Which class of drugs increase neurotransmitter release?

SV2A ligands increase release of GABA via exocytosis

5

Carbamazepine, Oxcarbazepine, Phenytoin (COPs)

- Na+ channel inhibitors
- Block AP propagation

6

Valproate, Ethosuximide, Topiramate (VET)

- Ca2+ channel blockers
- Decrease excitatory neurotransmission
- Ethosuximide & Valproate (T-type)
- Topiramate (N & L-type)

7

Ezogabine

K+ channel opener

8

Benzodiazepines

Enhance GABA activity

9

Phenytoin, Topiramate, Levetiracetam

Inhibit Glutamate activity

10

Which drug is a carbonic anhydrase inhibitor?

Topiramate

11

What are the DOCs for absence seizures?

Ethosuximide (ansence ONLY) & Valproate

12

What are the DOCs for focal seizures?

Phenytoin, Carbamazepine, Oxcarbazepine & Topiramate

13

What are the DOCs for generalized tonic-clonic seizures?

Topiramate & Valproate (TV)

14

What are the DOCs for myoclonic seizures?

Valproate, Levetiracetam (adjunctive tx) & Clonazepam (VLC)

15

What are the DOCs for Lennox-Gastaut seizures?

Clonazepam
(Adjunctive: Topiramate, Felbamate, Valproate, Lamotrigine, Rufinamide)

16

What is the order of tx for status epilepticus?

First line: Benzodiazepines
Second: Hydantoins & Valproate
Third: Barbituates
Fourth: IV Anesthetisa & Barbituates

17

Which AEDs can create a rash and exfoliation?

Phenytoin, Carbamazepine, Oxcarbazepine, Lamotrigine & Zonisamide

18

What are some SEs of AEDs?

1. Kidney stones (Topiramate, Zonisamide)
2. Anhydrosis/heat stroke (Topiramate)
3. Acute closed-angle glaucoma (Topiramate)
4. Hyonatremia & increases in ALT or AST, leukopenia, thrombocytopenia (Carbamazepine, Oxcarbazepine)

19

Which AEDs are at high risk for causing Stevens-Johnson Syndrome (aka toxic epidermal necrolysis)?

Carbamazepine, Lamotrigine & Valproate

20

Which AEDs are teratogenic?

Carbamazepine, Barbituates, Phenytoin, Oxcarbazepine, Valproate and Topiramate

21

Which AEDs causes gingival hyperplasia?

Phenytoin

22

Which AEDs induce the metabolism of other drugs?

Carbamazepine, Phenytoin & Phenobarbital

23

Which AED inhibits the metabolism of other drugs?

Valproate

24

Which AEDs are highly protein bound?

Valproate, Phenytoin, Carbamazepine, Oxcarbazepine, Topiramate