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Neuro Final > Anti-Epileptic Pharm-Kisby > Flashcards

Anti-Epileptic Pharm-Kisby Flashcards

1
Q

Which classes of drugs are ion channel inhibitors and openers?

A
  1. Na+ channel
  2. Ca2+ channel
  3. K+ channel
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2
Q

Which classes of drugs enhance GABA neurotransmission?

A
  1. GABAa receptor agonists
  2. GABA uptake inhibitors
  3. GABA transaminase inhibitors
  4. Glutamate decarboxylase activation
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3
Q

Which class of drugs reduce glutamate neurotransmission?

A

Glutamate receptors antagonists

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4
Q

Which class of drugs increase neurotransmitter release?

A

SV2A ligands increase release of GABA via exocytosis

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5
Q

Carbamazepine, Oxcarbazepine, Phenytoin (COPs)

A
  • Na+ channel inhibitors

- Block AP propagation

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6
Q

Valproate, Ethosuximide, Topiramate (VET)

A
  • Ca2+ channel blockers
  • Decrease excitatory neurotransmission
  • Ethosuximide & Valproate (T-type)
  • Topiramate (N & L-type)
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7
Q

Ezogabine

A

K+ channel opener

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8
Q

Benzodiazepines

A

Enhance GABA activity

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9
Q

Phenytoin, Topiramate, Levetiracetam

A

Inhibit Glutamate activity

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10
Q

Which drug is a carbonic anhydrase inhibitor?

A

Topiramate

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11
Q

What are the DOCs for absence seizures?

A

Ethosuximide (ansence ONLY) & Valproate

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12
Q

What are the DOCs for focal seizures?

A

Phenytoin, Carbamazepine, Oxcarbazepine & Topiramate

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13
Q

What are the DOCs for generalized tonic-clonic seizures?

A

Topiramate & Valproate (TV)

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14
Q

What are the DOCs for myoclonic seizures?

A

Valproate, Levetiracetam (adjunctive tx) & Clonazepam (VLC)

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15
Q

What are the DOCs for Lennox-Gastaut seizures?

A

Clonazepam

Adjunctive: Topiramate, Felbamate, Valproate, Lamotrigine, Rufinamide

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16
Q

What is the order of tx for status epilepticus?

A

First line: Benzodiazepines
Second: Hydantoins & Valproate
Third: Barbituates
Fourth: IV Anesthetisa & Barbituates

17
Q

Which AEDs can create a rash and exfoliation?

A

Phenytoin, Carbamazepine, Oxcarbazepine, Lamotrigine & Zonisamide

18
Q

What are some SEs of AEDs?

A
  1. Kidney stones (Topiramate, Zonisamide)
  2. Anhydrosis/heat stroke (Topiramate)
  3. Acute closed-angle glaucoma (Topiramate)
  4. Hyonatremia & increases in ALT or AST, leukopenia, thrombocytopenia (Carbamazepine, Oxcarbazepine)
19
Q

Which AEDs are at high risk for causing Stevens-Johnson Syndrome (aka toxic epidermal necrolysis)?

A

Carbamazepine, Lamotrigine & Valproate

20
Q

Which AEDs are teratogenic?

A

Carbamazepine, Barbituates, Phenytoin, Oxcarbazepine, Valproate and Topiramate

21
Q

Which AEDs causes gingival hyperplasia?

A

Phenytoin

22
Q

Which AEDs induce the metabolism of other drugs?

A

Carbamazepine, Phenytoin & Phenobarbital

23
Q

Which AED inhibits the metabolism of other drugs?

A

Valproate

24
Q

Which AEDs are highly protein bound?

A

Valproate, Phenytoin, Carbamazepine, Oxcarbazepine, Topiramate

Neuro Final (25 decks)

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