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Flashcards in Hypothalamus - Bales Deck (18):

Where is the major source of histamine in the CNS? What is this nucleus involved in?

the tuberomammillary nucleus of the LHA

this nucleus is involved in wakefulness (cortical arousal)

antihistamines will inhibit these neurons causing drowsiness.


What is produced ONLY in the lateral hypothalamus of the CNS? What does this play a role in? What does a dysregulation of this circuit cause?





What will stimulation of the lateral hypothalamus cause (in terms of food intake)? What about a lesion?

stimulation: hyperphagia (overeating)

lesion: anorexia


What is the role of the ventromedial hypothalamus? What would stimulation of the ventromedial hypothalamus cause? what about a lesion?

satiety center (determines when to stop eating)

stimulation==> anorexia (inhibits eating)

lesion==> hyperphagia (overeating)


What are anorexigenic and orexigenic molecules? How do they gain axis to the hypothalamus?

Anorexigenic (leptin) and orexigenic (ghrelin)

they gain access through the median eminence, one of the leaky-capillaried circumventricular organs (CVO)


What is the suprachiasmatic nucleus involved in? What does its output stimulate?

circadian rhythms

output stimulates pineal to secrete melatonin in the dark


What is the anterior hypothalamic nucleus involved in?

temperature regulation

anterior area has heat and cold sensitive neurons

at high temperature, it causes vasodilation and sweating to cause heat dissipation


How does the posterior hypothalamic nucleus regulate temperature?

causes heat conservation/production when the blood temperature is low

vasoconstriction and shivering


What can stimulation of the dorsomedial hypothalamic nucleus cause?

defensive-aggressive behaviors (“sham-rage”) in the absence of any contextual elicitors.


What are the two parts of the pituitary and what causes their difference in appearance in an H and E stain?

Adenohypophysis is secretory cell rich (dark, cell bodies stained with H&E)

Neurohypophysis is axon rich (pale, poorly stained with H&E)


Which 2 nuclei are involved in neuroendocrine regulation via the posterior pituitary? What pathway do they take to secrete hormones?

supraoptic and paraventricular nuclei

oxytocin and ADH are transported via the supraopticohypophyseal tract axons (magnocellular) to the posterior pituitary

nn terminals release hormones near the inferior hypophyseal A capillaries


What is the stimulus for the ADH secretion?

osmolality detecting neurons of the organum vasculosum of the lamina terminals (OVLT)


What is major function of the medial forebrain bundle (MFB)?

transmitting feedback from cervix (prepartum--> when cervix is distended) and breast (postpartum--> from suckling on the breast) to hypothalamus to stimulate oxytocin release


What is the paraventricular nucleus involved in? What would a lesion here cause?

it is a main regulator of the autonomic system (projecting to PNS and SNS preganglionic neurons)

Lesion here would cause ipsilateral Horner's syndrome


Which 2 nuclei are involved in neuroendocrine regulation via the anterior pituitary? Where do their axons terminate?

preoptic and arcuate nuclei (parvicellular)

axons terminate on the superior hypophyseal A capillaries in the median eminence --> dump regulatory hormones into the portal veins causing


What is a hamartoma? What can result from one in the hypothalamus?

disorganized tumor-like but non-neoplastic neural tissue elements

intractable epilepsy, precocious puberty and laughing seizures (gelastic)


What supplies blood to the hypothalamus?

multiple short direct brs. from circle of Willis


Where do the hypophyseal aa usually branch from?

the internal carotid artery (superior and inferior)