Anti-PD Pharm-Kisby Flashcards Preview

Neuro Final > Anti-PD Pharm-Kisby > Flashcards

Flashcards in Anti-PD Pharm-Kisby Deck (12):
1

L-Dopa

- Pro-drug that does not cross BBB
- Immediate precursor of dopamine
- Restore synaptic DA levels
- SE: dyskinesias (choreiform movements)

2

Entacapone & Tolcapone

- Selective and reversible COMT inhibitors
- Give with L-Dopa to increase efficacy
- SE: orange urine discoloration

3

Carbidopa

- Give with L-Dopa to increase efficacy

4

What is the "on-off" effect?

- Fluctuations in clinical response to L-Dopa
- Off = marked akinesia
- On = improved mobility but marked dyskinesia

5

When would you use DA receptor agonists?

As monotherapy in early PD and adjunct in late PD

6

Pramipexole, Ropinirole & Apomorphine

- DA receptor agonists
- SE: orthostatic hypotension, dykinesias, drowsiness, sleep attacks (Pramipexole)

7

Selegiline (good for young pt) & Rasagiline (good for elderly)

- Selective irreversible inhibitors of MAO-B
- MAO-B metabolizes dopamine
- Can get party food effect
- SE: hypertensive crisis, fatal hyperthermia

8

Trihexyphenidyl & Benzotropine

- Muscarinic receptor antagonists
- Decreases ACh in body
- Effective against tremors
- SE: mad as a hatter, hot as hades...

9

Amantidine

- Antiviral drug with anti-PD properties
- Reduces L-dopa induced dyskinesias via NMDA inhibition

10

What would you use to treat early onset PD?

Dopamine agonists (pramipexole, apomorphine, etc.)

11

What would you use to treat late onset PD?

L-dopa

12

What does a-synuclein build up cause?

Lewy-bodies