Flashcards in ageing and frailty Deck (10):
with time, a trend described as the rectangularization of survival curves has emerged, explain?
where the onset of morbidity/mortality is much more delayed, living longer lives thanks to modern medicine and public health initiatives.
cellular senescence is the phenomenon where cell lose the ability to [....]. in response to DNA damage, cells either [....[ or they [....] if the damage cant be repaired.
senesce or they self-destruct (apoptosis)
frailty phenotype involves the following 5 criteria: [....]
cases are pre-frail if they have [...]criteria
unintentional weight loss
slow walking speed
low physical activity
frailty is associated with a low grade, chronic activation of [.....], along with abnormalities of the [....] and coagulation systems.
The [....] Model of Frailty outlines a group of patient characteristics, where if present they can predict poorer outcomes.
The [....] Model of Frailty outlines an accumulation of defecits which occur with ageing that combine to increase the 'frailty index'--->increasing the risk of an adverse event
[....] is the loss of muscle mass and strength, it tends to occur after 50 years old, but accelerates after 60 years old.
In the process of sarcopenia, type [...] muscles fibres deteriorate faster than type [...] muscle fibres.
Type 2 muscle fibres are [...] twitch, meant for [....] types of movement. Type 1 muscle fibres are [...], meant for [....] movement.
Normally muscles are activated from distal to proximal, but as you age this reverses.
fine, precise rapid movement.
gross, sustained motor movement