ageing and frailty Flashcards Preview

MD2- Neuroscience Block > ageing and frailty > Flashcards

Flashcards in ageing and frailty Deck (10):
1

with time, a trend described as the rectangularization of survival curves has emerged, explain?

where the onset of morbidity/mortality is much more delayed, living longer lives thanks to modern medicine and public health initiatives.

2

cellular senescence is the phenomenon where cell lose the ability to [....]. in response to DNA damage, cells either [....[ or they [....] if the damage cant be repaired.

divide.

senesce or they self-destruct (apoptosis)

3

frailty phenotype involves the following 5 criteria: [....]

cases are pre-frail if they have [...]criteria

unintentional weight loss
weakness
exhaustion
slow walking speed
low physical activity

pre-frail
frail

4

frailty is associated with a low grade, chronic activation of [.....], along with abnormalities of the [....] and coagulation systems.

immune system
endocrine system.

5

The [....] Model of Frailty outlines a group of patient characteristics, where if present they can predict poorer outcomes.

Phenotype

6

The [....] Model of Frailty outlines an accumulation of defecits which occur with ageing that combine to increase the 'frailty index'--->increasing the risk of an adverse event

Deficit

7

[....] is the loss of muscle mass and strength, it tends to occur after 50 years old, but accelerates after 60 years old.

sarcopenia

8



In the process of sarcopenia, type [...] muscles fibres deteriorate faster than type [...] muscle fibres.

Type 2

Type 1

9

Type 2 muscle fibres are [...] twitch, meant for [....] types of movement. Type 1 muscle fibres are [...], meant for [....] movement.

Normally muscles are activated from distal to proximal, but as you age this reverses.

fast twitch
fine, precise rapid movement.

slow twitch
gross, sustained motor movement

10

a [.....] is one symptom or a complex of symptoms with high prevalence in geriatrics, resulting from multiple diseases and multiple risk factors.

geriatric syndrome