Drugs of Dependance and Antidepressants Flashcards Preview

MD2- Neuroscience Block > Drugs of Dependance and Antidepressants > Flashcards

Flashcards in Drugs of Dependance and Antidepressants Deck (20):
1

[...] describes a state where drug taking becomes compulsive, taking precedence over other needs

drug dependance

2

[...] describes a state where use of illicit substances is characterized by recurrent and clinically significant adverse events.

drug abuse

3

Where are the reward and salience circuits in the brain?

nucleus accumbens and ventral pallidum

4

Where are the memory and learning circuits in the brain?

hippocampus and amygdala

5

Where are the circuits for motivational drive in the brain?

orbitofrontal cortex and subcallosal cortex.

6

Where are the circuits for inhibitory control in the brain?

prefrontal cortex and anterior cingulate gyrus.

7

drugs of dependence act to increase [...] levels in the nucleus accumbens.

dopamine.

8

dopamine transmission can be modulated by any of the following NT's:

ACh, serotonin, NA,
GABA, glutamate,
opioids

9

[...] drugs (ex. morphine, heroine) produce CNS effects of euphoria

opiod

10

[....] drugs (ex. alcohol diazepam) produce CNS effects of reduced anxiety.

cns depressants

11

[....] drugs (cocaine, amphetamine, MDMA) produce CNS effects of excitement, increased energy.

cns stimulants.

12

[....] drugs (LSD) cause hallucinations.

Hallucinogens

13

[....] drugs (D-9-THC) cause altered pereption

cannabinoids

14

both cocaine and amphatemine, in the class of CNS [....], act to increase levels of [...] in the synaptic cleft.

cocaine does this by [...], while amphetamine stimulates [....].

these drugs also modulate the effect of NT's: [...]

stimulants
noradrenaline

inhibiting reuptake channels
release from storage vesicles.

dopamine and serotonin.

15

amphetamine produces mood [....], appetite [....], improves confidence and speed of performance on tasks with tradeoff being loss of [.....]. Amphetamine analogs can be used to treat [...].

elevation
suppression
accuracy

ADHD type disorders.

***Cocaine effects are essentially more dramatic versions of this.

16

caffeine is part of the drug class [....]. it is an [...] antagonist, a [....] inhibitor.

methylaxinine,
adenosine.
phosphodiesterase

17

LSD is a psychotomimetic drug that causes [......] hallucinations.

It acts as an agonist of [....] receptors in the CNS.

visual, auditory and tactile.

5-HT^2 receptors.

18

Methylene dioxy methamphetamine (Ecstasy) causes release and eventually, with continued use, the degeneration of [....]

dopamine and serotonin (5-HT) neurons.

19

evidence is presented that you can become addicted to marijuana because D9-THC (cannabinoids) can increase [....] neuronal firing by decreasing GABAergic inhibition of [.....] neural activity.

dopamine

dopamine

20

Ethanol acts as a CNS [...] by inhibiting {...] channel opening, enhancing NT [....] action, and inhibiting [....] receptors (NMDA type channels)

depressant
calcium ++
GABA action
glutamate receptors (NMDA type channels)