Flashcards in Drugs of Dependance and Antidepressants Deck (20):
[...] describes a state where drug taking becomes compulsive, taking precedence over other needs
[...] describes a state where use of illicit substances is characterized by recurrent and clinically significant adverse events.
Where are the reward and salience circuits in the brain?
nucleus accumbens and ventral pallidum
Where are the memory and learning circuits in the brain?
hippocampus and amygdala
Where are the circuits for motivational drive in the brain?
orbitofrontal cortex and subcallosal cortex.
Where are the circuits for inhibitory control in the brain?
prefrontal cortex and anterior cingulate gyrus.
drugs of dependence act to increase [...] levels in the nucleus accumbens.
dopamine transmission can be modulated by any of the following NT's:
ACh, serotonin, NA,
[...] drugs (ex. morphine, heroine) produce CNS effects of euphoria
[....] drugs (ex. alcohol diazepam) produce CNS effects of reduced anxiety.
[....] drugs (cocaine, amphetamine, MDMA) produce CNS effects of excitement, increased energy.
[....] drugs (LSD) cause hallucinations.
[....] drugs (D-9-THC) cause altered pereption
both cocaine and amphatemine, in the class of CNS [....], act to increase levels of [...] in the synaptic cleft.
cocaine does this by [...], while amphetamine stimulates [....].
these drugs also modulate the effect of NT's: [...]
inhibiting reuptake channels
release from storage vesicles.
dopamine and serotonin.
amphetamine produces mood [....], appetite [....], improves confidence and speed of performance on tasks with tradeoff being loss of [.....]. Amphetamine analogs can be used to treat [...].
ADHD type disorders.
***Cocaine effects are essentially more dramatic versions of this.
caffeine is part of the drug class [....]. it is an [...] antagonist, a [....] inhibitor.
LSD is a psychotomimetic drug that causes [......] hallucinations.
It acts as an agonist of [....] receptors in the CNS.
visual, auditory and tactile.
Methylene dioxy methamphetamine (Ecstasy) causes release and eventually, with continued use, the degeneration of [....]
dopamine and serotonin (5-HT) neurons.
evidence is presented that you can become addicted to marijuana because D9-THC (cannabinoids) can increase [....] neuronal firing by decreasing GABAergic inhibition of [.....] neural activity.