Allergy, Hypersensitivity Flashcards Preview

Stage 4 Immunology > Allergy, Hypersensitivity > Flashcards

Flashcards in Allergy, Hypersensitivity Deck (17)
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1

Which pathogen are chemicaly most similar to humans?

parasites

2

How are parasites removed from our bodt system?

Expelled through physcial force: coughing, sneezing

3

Which immune cells involved in eradicating parasites by creating an immune response?

Mast cells

Oesinophils

basophils

IgE

T helper 2 cells

4

Which hypothesis is involved with envoronmental susceptibility

Hygiene hypothesis

5

What is hygeiene hypothesis?

Those in urban enviro are more prone to develop allergy than people living in country

exposure to infection/allergen at childhood drives immune system towards non-atopy (non-allergic) state

6

Which in gentic suscptibility

Raised level of IgE: IL-4 (also IL-5, IL-13)
HLC Class II (ecode for MHC II)

7

Which are the Ab mediates hypsersentivity reactions? (immediate)

Type I - III

8

Which is the Ab mediates cell mediated hypsersentivity reactions?

Type IV

9

Which mediators are released immediately in Type 1 reaction?

Histamine

Herparin

TNF- alpha

10

What is the action of histamine?

Increase vasodilation and vascular permeability

Increase mucus secretion in airways

11

Which cells are recuited?

Granulocytes: basophil, neutrophil, eosinophils

TH2 lymphocytes

12

What do TH2 lymphocytes release

1. IL-5 which then recruit...

2. eosinophils and more IL-4, IL-14 which further activate...

3. B cells to produce IgE

13

Which cells are recruited by leukocytes?

Granulocytes: basophil, neutrophil, eosinophils

TH2 lymphocytes

14

Repeated bouts of allergen exposure cause?

Chronic inflammation in the area

E.g. Chronic asthma

15

What is a hypersensitivity reaction?

Inappropriate immune response causing tissue damage and other symptoms

e.g. allergy, infection, autoimmune

16

Which 2 routes of admin of allergen can cause anaphylaxic shock

IV

ingestion2

17

Which 2 routes of admin of allergen can cause anaphylaxic shock

IV

ingestion