Vaccines Flashcards

(13 cards)

1
Q

Where are memory cells renewed?

A

Bone marrow

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2
Q

How do memory B and T cells work on second event of infection (secondary response). 2 items.

A
  • activate to clear infection quicker

- activate mechanisms to SUPPRESS naive B and T cells from responding to the same pathogen

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3
Q

Which cells are more, effector cells or memory B and T cells during primary response?

A

Effector cells outnumber

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4
Q

What are the TWO most important contribution to public

health

A
  • Vaccination

- Sanitation

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5
Q

What are the 2 immunsations given

A
  1. Stimulates primary immune response - medicated by naive B and T cells
  2. Stimulates secondary immune response -mediated y memory B and T cells
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6
Q

Define: Vaccination

A

Medical procedure providing immunological memory of a pathogen without the individual needing to be infected initially by that pathogen

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7
Q

What is the problem with the memory cells suppressing the naive B and T cells upon secondary immune resposne?

A
  • Possibility of progressive genetic modifications through mutation of the virus strains (antigenic drift and shift)
  • must wait for ALL epitopes of the original antigen are lost for the naive B and T cells to work again… takes longer so you spend more time ill
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8
Q

When are memory B & T cells

produced?

A

During the secondary

response

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9
Q

What is a subunit vaccine made of?

A

Made of only part of a virus

in vitro using recombinant DNA

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10
Q

Which type of vaccine can induce

weak symptoms of the disease?

A

Live attenuated

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11
Q

Which route of admin mimicks physiological entry point of most pathogens?

A

via the mucosal surface (mucosa)

oral or intranasal

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12
Q

What is an adjuvant used for

A

Stimulate the immune

response

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13
Q

Describe Edward Jenners approach.

A

Inject cowpox (bovine) which gave immunisation (protection) against smallpox

Named the process: vaccination

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