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Stage 4 Immunology > Vaccines > Flashcards

Flashcards in Vaccines Deck (13)
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1

Where are memory cells renewed?

Bone marrow

2

How do memory B and T cells work on second event of infection (secondary response). 2 items.

- activate to clear infection quicker

- activate mechanisms to SUPPRESS naive B and T cells from responding to the same pathogen

3

Which cells are more, effector cells or memory B and T cells during primary response?

Effector cells outnumber

4

What are the TWO most important contribution to public
health

- Vaccination

- Sanitation

5

What are the 2 immunsations given

1. Stimulates primary immune response - medicated by naive B and T cells

2. Stimulates secondary immune response -mediated y memory B and T cells

6

Define: Vaccination

Medical procedure providing immunological memory of a pathogen without the individual needing to be infected initially by that pathogen

7

What is the problem with the memory cells suppressing the naive B and T cells upon secondary immune resposne?

- Possibility of progressive genetic modifications through mutation of the virus strains (antigenic drift and shift)

-must wait for ALL epitopes of the original antigen are lost for the naive B and T cells to work again... takes longer so you spend more time ill

8

When are memory B & T cells
produced?

During the secondary
response

9

What is a subunit vaccine made of?

Made of only part of a virus

(in vitro using recombinant DNA)

10

Which type of vaccine can induce
weak symptoms of the disease?

Live attenuated

11

Which route of admin mimicks physiological entry point of most pathogens?

via the mucosal surface (mucosa)

oral or intranasal

12

What is an adjuvant used for

Stimulate the immune
response

13

Describe Edward Jenners approach.

Inject cowpox (bovine) which gave immunisation (protection) against smallpox

Named the process: vaccination