Immune System 3 Flashcards Preview

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Flashcards in Immune System 3 Deck (29)
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1

Where are BCRs generated?

In the bone marrow

2

How is the B cell "tested" against self-antigens?

Bone marrow cells express cell-surface self antigens

B cell interacts with bone marrow

3

What happens when self antigen is recognised?

signals for apoptosis

4

What is the negative selection process in bone marrow also called?

Central tolerance process

5

How do B cells migrate from bone marrow to secondary lymphoid tissues (organs)?

Through circulation:
Blood and lymphatic vessels

AFFERENT lymphatic vessel

6

What do B cells differentiate into in the thymus?

Plasma cells

Memory cells

7

What is the use of B cell differentiation into a plasma cell?

Plasma cells produce IgM antibodies to fight pathogens causing infection

8

What is the use of B cell differentiation into a memory cell?

Memory cells remember the pathogen for faster production of antibodies in future events of infection

9

What do TCRs (T cell receptors) recognise?

Short peptide fragments bound to MHC

10

What do BCRs ( cell receptors) recognise?

Free antigens

11

Which cells are MHC1 molecules expressed on?

All nucleated cells

12

Which MHC class binds TCR to CD8 cytotoxic T cells?

MHC Class 1

13

Which MHC class binds TCR to CD4 helper T cells?

MHC Class 2

14

How many AAs involved in MHC1

8-10 AA (short peptides) bind between alpha-1 and alpha-2

15

How many AAs incolved in MHC2

>13 AA peptides bind between alpha-1 and alpha-2

16

Which cells are MHC2 expressed on?

APC
e.g. Macrophages, B cells, dendritic cells

17

In which follicle do plasma cells produce low affinity IgM antibodies?

Primary follicle

18

In which follicle do plasma cells produce high affinity IgG antibodies?

Secondary follicle

19

Where does the binding of antigen and MHC Class 1 occur (endogenous)?

Endoplasmic reticulum

20

Where does the binding of the antigen and MHC Class 2 occur (exogenous)?

Phagosome

21

What can an immature T cell recognize when they
leave the bone marrow and migrate into the
thymus?

Can recognise and respond to:

- self MHC plus foreign peptide (defence)

- self MHC plus self peptid

( No recognition of self-MHC)

22

Where does Rearrengement of the pre-TCR take place?

Bone marrow

23

Where does Positive selection take place?

Thymus (cortex)

24

Where does Negative selection take place?

Thymus (medulla)

25

Where does Antigen encounter with T cell take place?

Lymph node

26

Which cell activation is a mechanism
of adaptive immune response versus
intracellular bacteria?

T helper 1 cell activation

27

Which cell activation is a mechanism
of adaptive immune response to kill a
virus infected cell?

CD8 T cell activation

28

How is effector cell produced

Naive B cell activated by pathogen and T^FH cell (involved in B cell maturation)

29

What process must occur for T cells to acquire their effector functions (i.e. helper or cytotoxic)?

Co-stimulation