Disorders of the immune system Flashcards Preview

Stage 4 Immunology > Disorders of the immune system > Flashcards

Flashcards in Disorders of the immune system Deck (11)
Loading flashcards...
1

List the 4 types of evasion of immune defence

- Antigenic variation

- immunosuppression

- resistance to immune response

- concealment of antigen

2

What is the major difference between antigenic drift and shift?

Antigenic drift = mutation

Antigenic shift = recombination

3

Name the two major surface antigens involved in antigenic variation

Haemagglutinin

Neuroaminidase

4

What is the 'cloak effect' or 'invisible cloak' in the concealment of antigens?

Shielding the antigen from the hosts immune defence (detection and destruction)

5

List the 4 potential ways of evasion of immune defence via immunosuppression

- shield/inhibit opsonisation

- infect immune cells

- inhibit inflammation

- induce regulatory T cells

6

Which mechanism is used by the influenza virus to evade
the immune response?

Antigenic drift or shift

7

Which one is the most frequent group
of primary immunodeficiency?

B cell deficiency

8

Which cell is infected by the HIV virus and progressively
decline after years, causing immunosuppression and death?

CD4 T helper cells

(Thats why we check CD4 cell count in HIV)

9

Which stages are involved in the adaptive immune response of B cells for HIV"?

Antibody production

1) Neutralisation

2) Opsonisation

3) Complement activation

10

Which stages are involved in the adaptive immune response of T cells in HIV? q

Cytotoxic CD8 T cell activation

Interferon gamma release

TH1 cell response

11

Which of the following factors increase the risk to develop
an autoimmune disease?

- HLA genes

- hygiene hypothesis

- diversity of commensal microbiota

- exposure of infections and environmental toxins