Flashcards in Disorders of the immune system Deck (11)
List the 4 types of evasion of immune defence
- Antigenic variation
- resistance to immune response
- concealment of antigen
What is the major difference between antigenic drift and shift?
Antigenic drift = mutation
Antigenic shift = recombination
Name the two major surface antigens involved in antigenic variation
What is the 'cloak effect' or 'invisible cloak' in the concealment of antigens?
Shielding the antigen from the hosts immune defence (detection and destruction)
List the 4 potential ways of evasion of immune defence via immunosuppression
- shield/inhibit opsonisation
- infect immune cells
- inhibit inflammation
- induce regulatory T cells
Which mechanism is used by the influenza virus to evade
the immune response?
Antigenic drift or shift
Which one is the most frequent group
of primary immunodeficiency?
B cell deficiency
Which cell is infected by the HIV virus and progressively
decline after years, causing immunosuppression and death?
CD4 T helper cells
(Thats why we check CD4 cell count in HIV)
Which stages are involved in the adaptive immune response of B cells for HIV"?
3) Complement activation
Which stages are involved in the adaptive immune response of T cells in HIV? q
Cytotoxic CD8 T cell activation
Interferon gamma release
TH1 cell response