Immune System 2 Flashcards Preview

Stage 4 Immunology > Immune System 2 > Flashcards

Flashcards in Immune System 2 Deck (16)
Loading flashcards...
1

Name the four processes which occur as part of the induced innate response

- Phagocytosis

- Cytokine production and inflammation

- TLR activation

- NK cell activation

2

What do TLRs recognise and respond to?

Pathogen-associated molecular patterns (PAMPs)

Disease-associated molecular patterns (DAMPs)

3

How many sub-types of TLRs exist in humans?

10

4

What does the most common TLR recognise?

TLR7 recognises all ssRNA (single strand)
E.g. HIV, Measles, Influenza

5

Which TLR responds to dsRNA (double strand) e.g. Rotavirus ?

TLR3

6

Which cells express TLRs?

macrophages

dendritic cells

7

What are TLRs activated by in the macrophage?

Bacterial LPS

(lipopolysaccharides)

8

What does TLR activation lead to?

Signals the transduction pathway which activates NF-kB

9

What is NF-kB? What does it do?

Protein

Transcription factor that codes for pro-inflammatory cytokines: INF-alpha and INF-beta

10

What happens when TLRs are expressed in dendiritc cells?

Stimulates maturation of TLRs

11

Which TLR bind ssRNA virus such as the
HIV virus

TLR7

12

Which of the cytokine is
produced by NK cells in response to a
viral infection

INF gamma

Slows viral replication
Stimulates immune response

13

What is the first antibody to be
produced during an infection?

IgM

14

What is the second antibody to be
produced during an infection?

IgG

15

What is the first antibody to be
produced during an infection?

Chimeric

16

Suffix of chimeric monoclonal antibodies?

-omab

(O - oh no, fully derived from mice)