Aminogycosides & Anti-TB Drugs Flashcards
What drugs are rapidly bacteriocidal?
aminoglycosides
What is an aminoglycoside is most commonly used?
Gentomyacin
What antibiotic:
primarily used in aerobic, Gram - bacteria
Aminoglycosides
What are the side effects of aminoglycosides? (2)
Ototoxicity, irreversible
Nephrotoxicity, reversible
What 2 antibiotics should never be mixed in the same vial?
Aminoglycosides and PCNs!
What are some aminoglycosides? (5)
Gentamicin
Streptomycin
Amikacin
Neomycin
Kanamycin
What aminoglycoside:
1st discovered
Primarily used to treat multidrug resistant TB
Very toxic
Treats bacterial endocarditis
Streptomycin
What aminoglycoside:
Topical only for infections of skin, mucous
Neomycin
What aminoglycoside:
Preferred for P. aeruginosa infections
Gentomycin
What aminoglycoside:
Effective in infections with organisms resistant to gentamicin
Semi-synthetic
Most expensive
Amikacin
Mycobacterium tuberculosis, the microorganism that causes TBt survives within _________.
macrophages
What anti-TB drug inhibits mycolic acid?
Isoniazid
What is the DOC (in combination with another drug) for TB?
Isoniazid
What anti-TB drug:
Broad spectrum
Mostly Gram +
Inhibits RNA synthesis (RNA polymerase)
Rifampin
What 2 anti-TB drugs are the most highly effective combinations?
Isoniazid
Rifampin
