What are anti-folate drugs? (2)
What inhibits the synthesis of dihydrofolic acid?
What inhibits the synthesis of tetrahydrofolate?
Dihydrofolate is inhibitor of what?
bacteriostatic at _____ doses
bacteriocidal at _____ doses
______ is influenced by PABA analogs
What class is DOC for:
Prophylaxis of burn infections
Inflammatory disorders of the GI tract
What class is 2nd line DOC for:
What are the sulfonamides? (2)
irritable bowel disorder
What are adverse effects of sulfonamides? (6)
What acts synergistically with sulfonamide?
trimethoprim, (Co-trimoxazole), 1/10
Trimethoprim is a broad spectrum antibiotic. True or false?
What is DOC:
Urinary tract infections. Acute, chronic, recurrent
Chronic bacterial prostatitis
Pneumocystis carinii pneumonia in AIDS patients
What class of antibiotic is a DNA gyrase (topoisomerase II) inhibitor?
What are the fluoroquinolines? (4)
Fluoroquinolones have an after-drug effect. True or false?
Fluoroquinolines are most active again most aerobic Gram + bacteria. True or false?
False, Gram -
Are the fluoroquinolones well tolerated and safe for pregnant women or children < 18 y/o?
Yes, well tolerated but not safe for preggo and <18 y/o.
What are drug interactions of quinolones? (4)
P450 inhibition, potentiate theophylline toxicity
Divalent, trivalent cations
What fluoroquinolines inhibit P450? (2)
What fluoroquinoline is also known as inhalational anthrax?