Sufonamides, Trimethoprim, Quinolones Flashcards Preview

General Pharmacology > Sufonamides, Trimethoprim, Quinolones > Flashcards

Flashcards in Sufonamides, Trimethoprim, Quinolones Deck (22):
1

What are anti-folate drugs? (2)

Sulfonamides

Trimethoprim

2

What inhibits the synthesis of dihydrofolic acid?

Sulfonamides

 

3

What inhibits the synthesis of tetrahydrofolate?

Trimethoprim

4

Dihydrofolate is inhibitor of what?

Dihydrofolic acid

5

Sulfonamides are:

bacteriostatic at _____ doses

bacteriocidal at _____ doses

______ is influenced by PABA analogs

 

lower (systemic)

higher (urinary)

Efficacy

6

What class is DOC for:

Prophylaxis of burn infections
Inflammatory disorders of the GI tract

sulfonamides

7

What class is 2nd line DOC for:

respiratory infections
uncomplicated UTI

sulfonamides

8

What are the sulfonamides? (2)

Sulfisoxazole

Sulfasalazine

9

What sulfonamide:

rapidly absorbed
UTI
systemic infection

Sulfisoxazole

10

What sulfonamide:

poorly absorbed
irritable bowel disorder

Sulfasalazine

11

What are adverse effects of sulfonamides? (6)

crystalluria
hypersensitivity
GI disturbances
hemolytic disturbances
hyperbilirubinemia
N/V

12

What acts synergistically with sulfonamide? 

trimethoprim, (Co-trimoxazole), 1/10

13

Trimethoprim is a broad spectrum antibiotic.  True or false?

True

14

What is DOC:

Urinary tract infections.  Acute, chronic, recurrent
Chronic bacterial prostatitis
Pneumocystis carinii  pneumonia in AIDS patients

Trimethoprim

15

What class of antibiotic is a DNA gyrase (topoisomerase II) inhibitor?

Quinolones

16

What are the fluoroquinolines? (4)

Cipro

Floxin

Levofloxacin

Gatifoxacin

17

Fluoroquinolones have an after-drug effect.  True or false?

True

18

Fluoroquinolines are most active again most aerobic Gram + bacteria.  True or false?

False, Gram -

19

Are the fluoroquinolones well tolerated and safe for pregnant women or children < 18 y/o?

Yes, well tolerated but not safe for preggo and <18 y/o.

20

What are drug interactions of quinolones? (4)

P450 inhibition, potentiate theophylline toxicity

Caffeine

NSAIDs

Divalent, trivalent cations

21

What fluoroquinolines inhibit P450? (2)

Cipro

ofloxacin (Floxin)

22

What fluoroquinoline is also known as inhalational anthrax?

Cipro