Pharmacogenetics Flashcards Preview

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Flashcards in Pharmacogenetics Deck (13):
2

Drug polymorphism where there are alterations in target molecule is known as ______ polymorphism.

pharmacodynamic

3

What polymorphism is: usually due to alterations in drug metabolizing enzymes more prevalent due to lower selection pressure.

pharmacokinetic

4

Ways to detect pharmacogenetic traits: (2)

phenotyping
genotyping

5

What type of genetic test can: detect all mutant alleles, are affected by epigenetic factors, and can change with time?

phenotyping

6

What type of genetic testing: only detects known mutant alleles easily done by sequencing?

genotyping

7

Multiple defective alleles/haplotypes complicates _____ and limits ______.

genotyping
predictability

8

____ distribution can vary substantially between diffferent racial/ethnic groups

Alleles

9

This polymorphism results in: Affects a wide diversity of drugs Increased or prolonged response with most drugs

CYP 2D6 polymorphism

10

This polymorphism results in: a large number of mutant (defective alleles) is an autosomal recessive inheritance 10% of Caucasians and 1% Asians
Note: An autosomal recessive disorder means two copies of an abnormal gene must be present in order for the disease or trait to develop.

CYP 2D6

11

An extra copy of CYP 2D6 alleles causes _______ ______ in up to 7% of Caucasians. This can result in ____ ____ with standard drug doses.

ultrarapid metabolism
therapeutic failure

12

This polymorphism results in the inactivation of succinylcholine.

pseudocholinesterase, or serum cholinesterase

13

Mutations in _____ _____ _ are the most common cause of malignant hyperthermia

Ryanodine Receptor I

14

What factors can affect drug metabolism? (8)

age
hormones
metabolism
diet
smoking
herbal supplements
disease
alcohol