Amiodarone Flashcards
(13 cards)
What is the half-life of Amiodarone?
About 50 days
What may be required for Amiodarone treatment?
Loading doses may be required
Which functions should be monitored during Amiodarone treatment?
- Thyroid function
- Liver function
- Serum potassium
- Chest X-ray
- ECG (with intravenous use)
What are warning signs of Amiodarone use?
- Signs and symptoms of hypo- or hyperthyroidism
- Corneal microdeposits
- Progressive shortness of breath or cough
- Clinical signs of liver disease (e.g., jaundice)
- Neurological effects (e.g., tremor, peripheral neuropathy)
- Phototoxic skin reactions
What should be done if vision impairment occurs with Amiodarone?
Stop Amiodarone
What actions should be taken to protect the skin during Amiodarone treatment?
Advise patient to shield skin from direct sunlight and use a wide-spectrum sunscreen
How long after stopping Amiodarone may clinical effects persist?
For a few months
True or False: Amiodarone can cause dizziness in drivers at night.
True
What is a potential risk of drug interactions due to Amiodarone’s long half-life?
Drug interactions may occur for several weeks to months after treatment has been stopped
What drugs have increased plasma concentrations due to Amiodarone?
- Coumarins
- Dabigatran
- Digoxin
- Flecainide
- Phenindione
- Phenytoin
Which drugs increase the risk of ventricular arrhythmias when combined with Amiodarone?
- Amisulpride
- Atomoxetine
- Chloroquine
- Citalopram
- Disopyramide
- Escitalopram
- Haloperidol
- Hydroxychloroquine
- Levofloxacin
- Lithium
- Mizolastine
- Mefloquine
- Moxifloxacin
- Phenothiazines
- Pimozide
- Quinine
- Sulpiride
- Telithromycin
- Tolterodine
- Tricyclics
What is the increased risk when Amiodarone is given with beta-blockers?
Increased risk of bradycardia, AV block, and myocardial depression
Fill in the blank: Amiodarone increases the risk of myopathy when given with _______.
simvastatin
