Carbamezapine Flashcards
(16 cards)
What is the therapeutic range for Carbamazepine?
4 to 12mg/L (20 to 50 micromo/litre)
This range is crucial for effective treatment while minimizing toxicity.
What monitoring is required for Carbamazepine?
Full blood count, renal function, liver function
Regular monitoring helps detect potential adverse effects.
List some warning signs of Carbamazepine toxicity.
- Incoordination
- Blurred vision
- Diplopia
- Drowsiness
- Nystagmus
- Ataxia
- Arrhythmias
- Nausea and vomiting
- Diarrhoea
- Hyponatraemia
Awareness of these signs is essential for timely intervention.
What blood disorders are associated with Carbamazepine?
Leucopenia, thrombocytopenia
Symptoms include fever, sore throat, unexplained bruising or bleeding.
What skin disorders are linked to Carbamazepine?
Toxic epidermal necrolysis
Symptoms include mouth ulcers and rash.
What hepatic disorder can Carbamazepine cause?
Hepatitis
Liver function should be monitored regularly.
What syndrome is associated with Carbamazepine?
Antiepileptic Hypersensitivity Syndrome
Common symptoms are fever, rash, and swollen lymph nodes.
What is the major route of elimination for Carbamazepine?
Hepatic metabolism
Understanding the elimination pathway is important for dosage adjustments.
What actions should be taken if warning signs occur while on Carbamazepine?
Advise patient to report immediately to a doctor
Immediate reporting can prevent serious complications.
Why is it important for patients to receive the same brand of Carbamazepine?
To ensure consistent drug efficacy and safety
Different brands may have varying bioavailability.
What should patients be informed about regarding seizures and driving?
Patients should be aware of the law regarding seizures and driving
Legal implications can affect their ability to drive.
What interactions can increase plasma concentration of Carbamazepine?
- Acetazolamide
- Cimetidine
- Clarithromycin
- Erythromycin
- Fluoxetine
- Isoniazid
Increased concentrations can lead to toxicity.
What interactions can decrease plasma concentration of Carbamazepine?
- Phenytoin
- Rifabutin
- St. John’s Wort
Decreased concentrations may reduce therapeutic effects.
What effect does Carbamazepine have on other medications?
Reduces plasma concentration of antipsychotics, corticosteroids, coumarins, eplerenone, oestrogens, progestogens, simvastatin
This can lead to reduced effectiveness of these medications.
What can antagonize the anticonvulsant effect of Carbamazepine?
Mefloquine, antipsychotics
Co-administration of these drugs should be carefully monitored.
What is the possible risk when antiepileptics are given with orlistat?
Increased risk of convulsions
Caution is advised when combining these medications.
