Methotrexate Flashcards
(13 cards)
What is monitored during methotrexate treatment?
Full blood count, renal function, liver function
Local protocols for frequency of monitoring may vary
What are warning signs of gastro-intestinal toxicity from methotrexate?
Stomatitis
Gastro-intestinal toxicity can lead to significant discomfort and complications
What are warning signs of liver toxicity from methotrexate?
Jaundice, nausea, vomiting, abdominal discomfort, dark urine
Liver toxicity can indicate serious complications requiring immediate attention
What are symptoms of blood disorders due to methotrexate?
Sore throat, bruising, mouth ulcers, fever, rash
Bone marrow suppression can lead to serious health issues
What pulmonary toxicity can occur with methotrexate?
Pneumonitis
Symptoms include dyspnoea and cough
What actions are required for patients taking methotrexate?
Report warning signs to a doctor, take methotrexate once a week, take folic acid as prescribed, receive a treatment booklet
Patients must understand their treatment regimen clearly
Why is effective contraception important during methotrexate treatment?
Methotrexate can cause harm to a developing fetus
Counseling on contraception is crucial for women of childbearing age
What over-the-counter preparations should patients avoid while on methotrexate?
NSAIDs and aspirin
These can increase the risk of toxicity
What vaccination is recommended for patients on methotrexate?
Annual flu vaccine
Live vaccines should be avoided during treatment
What medications increase plasma concentration and risk of hepatotoxicity with methotrexate?
Acitretin
It is recommended to avoid this combination
What effect do NSAIDs and penicillins have on methotrexate excretion?
Reduce excretion, increasing risk of toxicity
Caution is advised when using these medications together
What is the risk when methotrexate is given with ciprofloxacin, doxycycline, tetracycline, sulfonamides, ciclosporin, proton pump inhibitors, or leflunomide?
Increased risk of toxicity
These medications can interact adversely with methotrexate
What is the increased risk associated with sulfamethoxazole (co-trimoxazole) or trimethoprim when combined with methotrexate?
Increased risk of haematological toxicity
Monitoring is essential when these drugs are used together
