Sodoum Valproate

Question 1

What is monitored in patients taking Sodium Valproate?

Answer 1

Liver function, full blood count, weight, BMI

Monitoring these parameters is crucial for the safe use of Sodium Valproate.

Question 2

What are warning signs associated with Sodium Valproate use?

Answer 2

Persistent vomiting, abdominal pain, anorexia, jaundice, oedema, malaise, drowsiness, loss of seizure control, suicidal ideation or behaviour

Recognizing these symptoms is important for timely intervention.

Question 3

What actions are required for women of childbearing age taking Sodium Valproate?

Answer 3

Enroll in a pregnancy prevention programme, understand risks in pregnancy, use effective contraception, have regular reviews and pregnancy tests

These protocols are essential to prevent fetal exposure to valproate.

Question 4

What must prescribers ensure regarding Sodium Valproate and pregnancy?

Answer 4

Patients understand the risks associated with valproate use in pregnancy and the need for effective contraception

Clear communication about these risks is vital for patient safety.

Question 5

What type of contraception is preferred for women of childbearing potential on Sodium Valproate?

Answer 5

User independent contraceptive method such as an IUD or implant, or two complementary forms including a barrier method

This helps ensure effective pregnancy prevention during treatment.

Question 6

How should Sodium Valproate therapy be initiated in women of childbearing age?

Answer 6

Not initiated without a negative pregnancy test and regular pregnancy tests throughout therapy

This is critical to prevent unintended pregnancies while on treatment.

Question 7

What vitamin supplementation may be necessary for patients immobilized for long periods?

Answer 7

Calcium supplementation

This is important for maintaining bone health in patients with limited mobility.

Question 8

What should be avoided when discontinuing Sodium Valproate?

Answer 8

Abrupt withdrawal

Gradual dose reduction over at least 4 weeks is recommended to prevent withdrawal seizures.

Question 9

What interactions can occur with Sodium Valproate?

Answer 9

Potentiation of effects of psychotropics, increased anticoagulant effect of warfarin, reduced metabolism of lamotrigine, increased valproic acid plasma levels by erythromycin and cimetidine, decreased plasma concentrations by enzyme-inducing anti-epileptics

These interactions can lead to increased toxicity or decreased efficacy of medications.