Sulfasalzaine

Question 1

What is the primary monitoring requirement for patients on Sulfasalazine?

Answer 1

Full blood count, renal function, urea and electrolytes, liver function

Regular monitoring is crucial to assess the impact of Sulfasalazine on these parameters.

Question 2

What warning signs should patients on Sulfasalazine be aware of?

Answer 2

• Malaise, fever, sore throat and other signs of infection
• Unexplained bruising
• Jaundice

These symptoms may indicate serious side effects that require immediate attention.

Question 3

What is a common side effect of Sulfasalazine regarding body fluids?

Answer 3

Yellow-orange discoloration of urine, other body fluids, and skin

Patients should be informed about this discoloration to avoid unnecessary concern.

Question 4

What advice should be given to patients regarding contact lenses while on Sulfasalazine?

Answer 4

Some soft contact lenses may be stained

Patients should consider using alternative lens options during treatment.

Question 5

What is the recommended action to correct folic acid deficiency caused by Sulfasalazine?

Answer 5

Using folic acid supplements

Sulfasalazine inhibits the absorption and metabolism of folic acid.

Question 6

In which patients should Sulfasalazine be used with caution?

Answer 6

Patients with G-6-PD deficiency

Use may lead to haemolytic anaemia in these individuals.

Question 7

What interaction does Sulfasalazine have with digoxin?

Answer 7

Reduced absorption of digoxin resulting in sub-therapeutic plasma levels

Monitoring digoxin levels is essential in patients taking both medications.

Question 8

What potential effect can Sulfasalazine have when used with 6-mercaptopurine or azathioprine?

Answer 8

Bone marrow suppression and leucopenia

These interactions can increase the risk of infections and other complications.