Anaesthesia: Intro and Sedation and Premedication Flashcards

1
Q

What is general anaesthesia?

A

The physiological state between being conscious and dead- the maintenance of ‘sleep’

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2
Q

What is the job of a vet for anaesthesia?

A

To anticipate, mitigate and minimise the risk of morbidity or mortality by:
Adequate preparation
Stabilisation
Protocol planning
Delivery
Monitoring

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3
Q

What are some general considerations of anaesthesia?

A

ASA status, aim of the anaesthesia, nature of the procedure, surrounding, equipment, knowledge, helpers

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4
Q

What skills are needed for anaesthesia?

(Day 1 Competencies)

A
  • Ensure patient airway
  • Giving O2
  • Know how to apply IPPV- intermittent positive pressure ventilation
  • IV catheter- give drugs IV
  • Basic CPCR
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5
Q
A
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6
Q

Outline the general process of anaesthesia?

A

Premedication

Induction

Maintenance

Recovery

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7
Q

What is the ASA and what is the ASA status?

A

ASA is the american society of anesthesiologists

ASA status is the general health of the animal and the patient risk

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8
Q

What are the different ASA classifications?

A

ASA 1- Normal healthy animals

ASA 2- Mild systemic disease

ASA 3- Moderate systemic disease

ASA 4- Severe systemic disease, constant life threat

ASA 5- Moribund, not expected to survive following 24 hours

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9
Q

What ate the three aims of anaesthesia?

A

Unconsciousness

Analgesia

Muscle relaxation

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10
Q

What is balenced anaesthesia and what are the benefits of it?

A

Anaesthesia produced by safe doses of two or more agents or methods of anaesthesia, each of which contributes to the total desired effect

Benefits: reduction of dose of each component, reduction of the side effects, optimised post-operative analgesia

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11
Q

How does nature of the procedure influence general anaesthesia?

A

Duration of procedure

Pain level of procdure

Localisation- head/neck eg

Recovery time

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12
Q

How is analgesia managed in anaesthestic protocol?

A

Pre-emptive analgesia= treat pain before

Part of balanced anaesthesia/analgesia = reduction of requirment

Analgesia during recovery

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13
Q

What equimpent is needed for general anesthesia?

A

Depends but generally:

Oxygen source

Anaesthetic machine

Breathing system

IPPV/ventilator

Venous access/ infusion pumps

Monitoring

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14
Q

What is the risk of mortality of humans, cats, rabbits and horses?

A

1 in 2000 humans

0.11% of cats

just under 1 in 100 rabbits

1 in 100 horses will die

Most important factor is pre-exisitng disease

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15
Q

What is the difference between sedation and premedication?

A

Sedation:
may be used as an alternative to general anaesthesia
Non-invasive procedures
Non-painful procedures

Premedication- administered prior to anaesthesia

Terms often used interchangeably

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16
Q

Why sedate instead of premed?

A

To relieve patient anxiety

Facilitate handling

Analgesia

Muscle relaxation

To enable procedures

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17
Q

Why premedicate instead of sedate?

A

Smooth induction of anaesthesia

Smooth maintenance of GA

Smooth recovery of GA

Reduce required dose of induction/maintenance

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18
Q

What would the ideal premed or sedative do?

A

Relieve fear/anxiety

Be safe

Reliable and predictable effect

Quick onset, appropriate duration of action

Easy to administer (route, volume, non-irritating)

Minimal CV, Resp and other side effects

Provide analgesia

19
Q

How can the cascade be used for sedatives and premeds?

A

Use the cascade to your advantage

Drugs for food producing animals must have an MRL

Use drugs to provide adequate analgesia

Use drugs to provide adequate sedation

20
Q

What are considerations of sedation and premed?

A
  • Reason for sedation/premed
  • What drugs you can use- food producing/cascade
  • Will there be pain
  • Are your drugs safe to use in this case
  • Will your drugs effectively sedate this patient
  • What if it doesn’t work?
21
Q

Why would you sedate/premed pre-appointment and what are your options?

A

For use of patients who are known to be anxious

Equine- acepromazine oral gel, detomodine oromucosal gel

Dogs and Cats- gabapentin 2 hours before appointment, Trazadone- caution if history of seizures

22
Q

What opioids could be used for sedation/premed what are the advantages and problems?

A

Butorphanol

Buprenorphine

Methadone

Fentanyl

(morphine)

Advantages- may be adequate alone, often good sedation if the animal presents very painful

Disadvantages- Respiratory depression

23
Q

What phenothiazines could be used for premed/sedation?

A

Acepromazine

24
Q

What alpha 2 receptor agonists could be used for sedation/premed?

A

Xylazine, Detomidine, Romifidine, Medetomidine, Dexmedetomidine

Sympathomimetics

25
What benzodiazepines can be used for sedation/premed?
Diazepam, midazolam affect GABA receptors GABA is exitatory
26
What adjuncts can be used for sedation/premed? PAK
Propfol Alfaxalone Ketamine
27
What is acepromazine sedation/premed useful for? What are its side effects? How long is the onset? What are the problems?
Useful for: Mitral valve disease cases Patients with BOAS Laryngeal paralysis/URT disease In combination with alpha-2 agonist for background calming effect Side effects- vasodilation Onset 20-40 minutes Problems- unreliable sedation, no analgesia, not reversible, long duration of action Has moderate MAC sparing effect
28
What is acepromazine not suitable for?
Very young patients \<3 months Hepatic impairment Haemorrhage (actual or anticipates) Anticipated hypotension during general anaesthesia Sepsis
29
What are alpha 2 agonists useful for? What are its side effects? How long is it's onset?
Useful for: All adult horses, Farm animals, Most dogs/cats Side effects: peripheral vasoconstriction/reflex bradycardia, reduced cardiac contractility, increased urine production Onset- depends on route: IV almost immediate, very reliable sedation
30
1. What is the sedation of alpha 2 agonists like? 2. Does it give analagesia? 3. Is it reversible? 4. How long does it last? 5. Small or large MAC sparing effect?
1. Very reliable sedation 2. Does give analgesia 3. Is reversible- atipamezole 4. Duration depends on drug and dose 5. Large MAC sparing effect
31
When are alpha 2 agonists not suitable?
Mitral valve disease Very yound \<3 months Resulting bradycardia may be a problem Urinary obstruction
32
1. What are bezodiazepines useful for? 2. How long is onset? 3. What are their side effects? 4. What is the sedation like? 5. Does it give analgesia? 6. Is it reversible 7. What is the MAC sparing effect like?
1. Useful for very young, very old, very sick 2. Depends on ROA- IV 5 mins 3. Minimal side effects 4. Sedation unreliable 5. No analgesia 6. Is reversible- flumazenil 7. Moderate MAC sparing effect
33
When are benzodiazepines not suitable?
Farm Animals Potrosytemic Shunt cases
34
What are the options for adjuncts and wht are they used?
Adjuncts 'help things along' Propofol Alfaxalone Ketamine- more analgesia, increased sedation reliability Physical restaints- not suitable for analgesia
35
How do you decide on route of administration?
Safety Minimal stress Will the drug work through said route?
36
How could you administer opioids?
IV- rapid onset IM SC- less reliable TM- fentanyl
37
How can you administer acepromazine and what varies with ROA?
IV- lower doses IM SC Oral- gel in horses, tablets in dogs/cats- less reliable Sedation onset similar
38
How can Alpha 2 agonists be administered how do ROA vary?
IV- rapid onset, lower doses IM SC- less reliable TM
39
How can you administer benzodiazepines what varys with ROA?
IV- more rapid onset, lower doses- could have paradoxical effect IM- midazolam- less reliable Oral- diazepam, not cats Rectal
40
What can be given to food producing animals for sedation/premed?
Butorphanol Xylazine- very sensitive Detomidine Azaperone- for pigs Recumbancy following alpha 2 agonists administration
41
What adjuncts can be used for food producing animals?
Physical retraint Ketamine Ear twitch Nose pliers Crush
42
What drugs can be administered for Equidae?
Alpha 2 agonists give reliable sedation of adult horses Choose drug to provide appropriate duration of sedation Alpha 2 agonists first, opioid 5 mins later Acepromazine to smooth recovery- not colic
43
What adjuncts can be usefd for horses?
Neck twitch Ear twitch Twitch
44
What is usually used for dogs and cats sedation/premed?
Alpha 2 receptor agonists very reliable Acepromazine useful for calming for long duration Benzodiazepines if very old, sick, young