Analgesic Drugs Flashcards Preview

STEP 1 > Analgesic Drugs > Flashcards

Flashcards in Analgesic Drugs Deck (15)
1

Name the opioids

morphine, fentanyl, codeine, loperamide, methadone, meperidine, dextromethrophan, diphenoxylate, pentazocine

2

Mechanism of opioids

act as agonists at opioid receptors to modulate synaptic transmission
- opens K+ channels, closes Ca2+ channels --> decreased synaptic transmission
inhibits release of Ach, NE, 5-HT, glutamate, substance P

3

Name the opioid receptors

mu = morphine
lambda = enkephalin
kappa = dynorphin

4

Use of opioids

pain, cough suppression (dextromethorphan), diarrhea (loperamide, diphenoxylate), acute pulmonary edema, maintenance programs for heroin addicts (methadone, buprenorphine + naloxone)

5

Name the opioid used for cough suppression

dextremethorphan

6

Name the opioids used for diarrhea

loperamide
diphenoxylate

7

Name the opioids used for heroin addicts

methadone
buprenorphine + naloxone

8

Toxicity of opioids

addiction, respiratory depression, constipation, miosis (pinpoint pupils), additive CNS depression with other drugs
don't develop tolerance to constipation and miosis

9

Treatment of opioid toxicity/overdose

naloxone or naltrexone which are opioid receptor antagonists

10

Mechanism of butorphanol

kappa-opioid receptor agonist and mu-opioid receptor partial agonist so can produce analgesia

11

Use of butorphanol

severe pain (e.g. migraine, labor)
causes less respiratory depression than full opioid agonists

12

Toxicity of butorphanol

can cause opioid withdrawal symptoms if patients is also taking full opioid agonist (competition for opioid receptors)
overdose not easily reversed with naloxone

13

Mechanism of tramadol

weak opioid agonist; also inhibits 5-HT and NE reuptake (works on multiple NTs)

14

Use of tramadol

chronic pain

15

Toxicity of tramadol

similar to opioids
decreases seizure threshold
serotonin syndrome