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Flashcards in Cholesterol Drugs Deck (18)
1

Name the HMG-CoA Reductase inhibitors

"-statins"

lovastatin, pravastatin, simvastatin, atorvastatin, rosuvastatin

2

Effect of HMG-CoA reductase inhibitors on LDL, HDL and TG

greatly decrease LDL
increase HDL
decrease LDL

3

Mechanism of HMG-CoA reductase inhibitors

inhibit conversion of HMG-CoA to mevalonate, a cholesterol precursor
decrease mortality in CAD pts

4

Side effects of HMG-CoA reductase inhibitors

hepatotoxicity (increased LFTs)
myopathy (esp when used with fibrates or niacin)

5

Name the bile acid resins

Cholestyramine, colestipon, colesevelam

6

Effect of bile acid resins on LDL, HDL and TGs

decrease LDL
slight increase in HDL
slight increase in TGs

7

Mechanism of bile acid resins

prevent intestinal reabsorption of bile acids
liver must use cholesterol to make more

8

Side effects of bile acid resins

GI upset, decreased absorption of other drugs and fat-soluble vitamins (ADEK)

9

Effect of ezetimibe on LDL, HDL, TGs

decreases LDL
no change in HDL or TGs

10

Mechanism of ezetimibe

prevent cholesterol absorption at small intestine brush border

11

Side effects of ezetimibe

rare increase in LFTs, diarrhea

12

Name the fibrates

Gemfibrozil, clofibrate, bezafibrate, fenofibrate

13

Effect of fibrates on LDL, HDL and TGs

decreases LDL
increases HDL
greatly decreases TGs

14

Mechanism of fibrates

upregulate LPL --> increased TG clearance
activates PPAR-alpha to induce HDL synthesis

15

Side effects of fibrates

myopathy (increased risk with statins)
cholesterol gallstones

16

Effect of niacin (B3) on LDL, HDL and TGs

decreases LDL
greatly increases HDL
decrease in TGs

17

Mechanism of niacin

inhibits lipolysis (hormone-sensitive lipase) in adipose tissue
reduces hepatic VLDL synthesis

18

Side effects of niacin

Red, flushed face, which is decreased by NSAIDs or long-term use
hyperglycemia
hyperuricemia