Anti-epileptic Drugs Flashcards Preview

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Flashcards in Anti-epileptic Drugs Deck (14)
1

Use of ethosuximide

absence seizures

2

Major side effects of ethosuximide

EFGHIJ - Ethosuximide causes fatigue, GI, headache, itching, Stevens-Johnson syndrome

3

Mechanism of ethosuximide

blocks thalamic T-type Ca2+ channels

4

Use of benzodiazepines

STATUS EPILEPTICUS (first line for acute)

also use for eclampsia seizures (1st line is MgSO4)

5

Use of phenytoin

first line for tonic-clonic
first line prophylaxis for status epilepticus

6

Side effects of phenytoin

INDUCES cytochrome P450 - AMPS it UP
SLE-like syndrome

7

Use of carbamazepine

first line for:
- partial simple and complex
- tonic-clonic

also first line for trigeminal neuralgia

8

Side effects of carabamazepine

INDUCTION of cytochrome p450
SIADH
Stevens-Johnson syndrome
Teratogen

9

Use of valproic acid

First line for tonic-clonic seizures

First choice for combined tonic-clonic and absence seizures!!!

also use for myoclonic seizures, bipolar disorder

10

Side effects of valproic acid

teratogen - neural tube defects

11

Use of gabapentin

peripheral neuropathy, postherpetic neuralgia

12

What is Stevens-Johnson syndrome?

prodrome of malaise and fever followed by rapid onset of erythematous/purpuric macules (oral, ocular, genital)
skin lesions progress to epidermal necrosis and sloughing

13

Use of phenobarbital

first line in neonates

14

Side effect of phenobarbital

INDUCES cytochrome p450