Monoclonal Antibodies Flashcards Preview

STEP 1 > Monoclonal Antibodies > Flashcards

Flashcards in Monoclonal Antibodies Deck (15)
1

Alemtuzumab (target and use)

Target: CD52
Use: CLL

aLYMtuzumab - chronic LYMphocytic leukemia

2

Bevacizumab (target and use)

Target: VEGF
Use: colorectal cancer, renal cell carcinoma, neovascular age-related macular degeneration

3

Cetuximab (target and use)

Target: EGFR
Use: stage IV colorectal cancer, head and neck cancer

4

Rituximab (target and use)

Target: CD20
Use: B-cell non-Hodgkin lymphoma, CLL, RA, ITP

5

Trastuzumab (target and use)

Target: HER-2/neu
Use: Breast cancer

6

Adalimumab and Infliximab (target and use)

Target: TNF-alpha (soluble)
Use: IBD, RA, ankylosing spondylitis, psoriasis

NOTE: Etanercept is a TNF-alpha receptor NOT monoclonal antibody

7

Eculizumab (target and use)

Target: complement protein C5
Use: paroxysmal nocturnal hemoglobinuria (DAF/GPI link deficiency)

8

Natalizumab (target and use)

Target: alpha4-integrin
Use: mutliple sclerosis, Crohn's disease

9

Special consideration with Natalizumab

alpha4-integrin important for WBC adhesion
risk of PML in patients with JC virus

10

Abciximab (target and use)

Target: platelet glycoproteins IIb/IIIa
Use: antiplatlet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention

2 x 3 = abSIXimab

11

Denosumab (target and use)

Target: RANKL
Use: osteoporosis (inhibits osteoclast maturation)

12

Digoxin immune Fab (target and use)

Target: Digoxin
Use: antidote for digoxin toxicity

13

Omalizumab (target and use)

Target: IgE
Use: Allergic asthma (prevents IgE binding to FceRI)

14

Palivizumab (target and use)

Target: RSV F protein
Use: RSV prophylaxis for high-risk infants

15

Ranibizumab (target and use)

Target: VEGF
Use: neovascular age-related macular degeneration