Inflammatory Drugs Flashcards Preview

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Flashcards in Inflammatory Drugs Deck (17)
1

Mechanism of acetaminophen

reversibly inhibits cyclooxygenase, mostly in CNS, inactivated peripherally

2

Use of acetaminophen

antipyretic, analgesic, NOT anti-inflammatory

use instead of aspirin in CHILDREN

3

Toxicity of acetaminophen

Hepatic necrosis due to overdose

NAPQI is toxic metabolite that depletes glutathione stores

4

Antidote to acetaminophen overdose

N-acetylcysteine which regenerates the glutathione stores

5

Mechanism of aspirin

irreversibly inhibits cyclooxygenase (1 and 2) via acetylation
decreases synthesis of TXA2 (increase bleeding time) and prostaglandins

increased bleeding time but NO effect on PT or PTT

6

Toxicity of aspirin

gastric ulceration, tinnitus (CN VIII)

chronic use: acute renal failure, interstitial nephritis, GI bleeding

cause respiratory alkalosis early, transitions to mixed metabolic acidosis-respiratory alkalosis

7

Toxicity of aspirin in CHILDREN

REYE syndrome in children treated with aspirin for viral infection

8

Mechanism of celecoxib

reversibly inhibits COX-2 found in inflammatory cells, vascular endothelium

9

Use of celecoxib

analgesic and anti-inflammatory

rheumatoid arthritis, osteoarthritis

10

Benefit of COX2 specific versus non-selective

spares COX1 thus:
- able to maintain gastric mucosa
- platelet function intact

11

Toxicity of celecoxib

increased risk of thrombosis, sulfa allergy

12

Name the NSAIDs

ibuprofen, naproxen, indomethacin, ketorolac, diclofenac

13

Mechanism of NSAIDs

reversibly inhibits cyclooxygenase (1 and 2)
blocks prostaglandin synthesis

14

Use of NSAIDs

antipyretic, anti-inflammatory, analgesic

15

Specific use of indomethacin

to close the PDA

16

Toxicity of NSAIDs

interstitial nephritis
gastric ulcer (prostaglandins protect gastric mucosa)
renal ischemia (prostaglandins dilate afferent arterioles)

17

Use of aspirin

low dose for decreased platelet activity
intermediate dose for anti-pyretic and analgesic
high dose for anti-inflammatory